Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2

Yoko Okitsu; Shinichiro Takahashi; Naoko Minegishi; Junichi Kameoka; Mitsuo Kaku; Masayuki Yamamoto; Takeshi Sasaki; Hideo Harigae

doi:10.1016/j.bbrc.2007.10.031

Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2

Yoko Okitsu, Shinichiro Takahashi, Naoko Minegishi, Junichi Kameoka, Mitsuo Kaku, Masayuki Yamamoto, Takeshi Sasaki, Hideo Harigae

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

GATA-2 is a transcription factor expressed in stem and progenitor cells of various cell lineages. In this study, we examined the role of GATA-2 in the differentiation of adipocytes, which are the main components of the microenvironment for hematopoiesis. Suppression of GATA-2 in TBR343, a preadipocytic stromal cell line, resulted in the acceleration of adipocyte differentiation. Conversely, overexpression of GATA-2 induced the resistance of adipocyte differentiation. In addition, regulatory elements of the GATA-2 gene in TBR343 are the same as those in hematopoietic cells. These results suggest that GATA-2 maintains a hematopoietic microenvironment by regulating the differentiation of adipocytes.

Original language	English
Pages (from-to)	383-387
Number of pages	5
Journal	Biochemical and biophysical research communications
Volume	364
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2007.10.031
Publication status	Published - 2007 Dec 14

Keywords

Adipocyte differentiation
Bone marrow
GATA-2

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. / Okitsu, Yoko; Takahashi, Shinichiro; Minegishi, Naoko; Kameoka, Junichi; Kaku, Mitsuo; Yamamoto, Masayuki; Sasaki, Takeshi; Harigae, Hideo.

In: Biochemical and biophysical research communications, Vol. 364, No. 2, 14.12.2007, p. 383-387.

Research output: Contribution to journal › Article › peer-review

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abstract = "GATA-2 is a transcription factor expressed in stem and progenitor cells of various cell lineages. In this study, we examined the role of GATA-2 in the differentiation of adipocytes, which are the main components of the microenvironment for hematopoiesis. Suppression of GATA-2 in TBR343, a preadipocytic stromal cell line, resulted in the acceleration of adipocyte differentiation. Conversely, overexpression of GATA-2 induced the resistance of adipocyte differentiation. In addition, regulatory elements of the GATA-2 gene in TBR343 are the same as those in hematopoietic cells. These results suggest that GATA-2 maintains a hematopoietic microenvironment by regulating the differentiation of adipocytes.",

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AU - Sasaki, Takeshi

AU - Harigae, Hideo

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