Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2

Yoko Okitsu, Shinichiro Takahashi, Naoko Minegishi, Junichi Kameoka, Mitsuo Kaku, Masayuki Yamamoto, Takeshi Sasaki, Hideo Harigae

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

GATA-2 is a transcription factor expressed in stem and progenitor cells of various cell lineages. In this study, we examined the role of GATA-2 in the differentiation of adipocytes, which are the main components of the microenvironment for hematopoiesis. Suppression of GATA-2 in TBR343, a preadipocytic stromal cell line, resulted in the acceleration of adipocyte differentiation. Conversely, overexpression of GATA-2 induced the resistance of adipocyte differentiation. In addition, regulatory elements of the GATA-2 gene in TBR343 are the same as those in hematopoietic cells. These results suggest that GATA-2 maintains a hematopoietic microenvironment by regulating the differentiation of adipocytes.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalBiochemical and biophysical research communications
Volume364
Issue number2
DOIs
Publication statusPublished - 2007 Dec 14

Keywords

  • Adipocyte differentiation
  • Bone marrow
  • GATA-2

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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