Regiospecificity in the cyclization of 6-(1-hydroxyalkyl) geraniol derivatives. A simple route to the taxol a-ring system

Takayuki Doi, Jeremy Robertson, Gilbert Stork, A. Yamashita

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Readily available derivatives of geraniol bearing a 1-hydroxyalkyl side chain in the 6-position undergo acid-catalyzed regiospecific cyclization to form cyclogeraniol derivatives which have an interesting relation to ring A of taxol.

Original languageEnglish
Pages (from-to)1481-1484
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number10
DOIs
Publication statusPublished - 1994 Mar 7
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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