Regioselective synthesis of flavone derivatives via DMAP-catalyzed cyclization of o-alkynoylphenols

Masahito Yoshida, Yuta Fujino, Koya Saito, Takayuki Doi

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

A catalytic amount of DMAP promoted cyclization of o-alkynoylphenols via a 6-endo cyclization mode leading to flavone derivatives in high yields without forming 5-exo cyclized aurone derivatives. Utilizing this method, methoxy substituted flavone and alkyl substituted γ-benzopyranone derivatives were synthesized.

Original languageEnglish
Pages (from-to)9993-9997
Number of pages5
JournalTetrahedron
Volume67
Issue number51
DOIs
Publication statusPublished - 2011 Dec 23

Keywords

  • 6-endo Cyclization
  • Flavones
  • Regioselective cyclization
  • Ynones

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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