Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease: A combined positron emission tomography/magnetic resonance imaging study

Daichi Sone; Etsuko Imabayashi; Norihide Maikusa; Nobuyuki Okamura; Shozo Furumoto; Yukitsuka Kudo; Masayo Ogawa; Harumasa Takano; Yuma Yokoi; Masuhiro Sakata; Tadashi Tsukamoto; Koichi Kato; Hiroshi Matsuda

doi:10.1016/j.dadm.2017.07.001

Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease: A combined positron emission tomography/magnetic resonance imaging study

Daichi Sone, Etsuko Imabayashi, Norihide Maikusa, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Masayo Ogawa, Harumasa Takano, Yuma Yokoi, Masuhiro Sakata, Tadashi Tsukamoto, Koichi Kato, Hiroshi Matsuda

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Introduction Molecular imaging and selective hippocampal subfield atrophy are a focus of recent Alzheimer's disease (AD) research. Here, we investigated correlations between molecular imaging and hippocampal subfields in early AD. Methods We investigated 18 patients with early AD and 18 healthy control subjects using ¹¹C-Pittsburgh compound-B (PIB) positron emission tomography (PET) and ¹⁸F-THK5351 PET and automatic segmentation of hippocampal subfields with high-resolution T2-weighted magnetic resonance imaging. The PET images were normalized and underwent voxelwise regression analysis with each subregion volumes using SPM12. Results As for ¹⁸F-THK5351 PET, the bilateral perirhinal cortex volumes were significantly associated with the ipsilateral or bilateral temporal lobar uptakes, whereas hippocampal subfields showed no correlations. ¹¹C-PIB PET showed relatively broad negative correlation with the right cornu ammonis 3 volumes. Discussion Regional tau deposition was correlated with extrahippocampal subregional atrophy and not with hippocampal subfields, possibly reflecting different underlying mechanisms of atrophy in early AD. Amyloid might be associated with right cornu ammonis 3 atrophy.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	9
DOIs	https://doi.org/10.1016/j.dadm.2017.07.001
Publication status	Published - 2017

Keywords

Alzheimer's disease
Entorhinal cortex
Hippocampal subfield
Perirhinal cortex
Tau PET

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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Sone, D., Imabayashi, E., Maikusa, N., Okamura, N., Furumoto, S., Kudo, Y., Ogawa, M., Takano, H., Yokoi, Y., Sakata, M., Tsukamoto, T., Kato, K., & Matsuda, H. (2017). Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease: A combined positron emission tomography/magnetic resonance imaging study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 9, 35-40. https://doi.org/10.1016/j.dadm.2017.07.001

Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease : A combined positron emission tomography/magnetic resonance imaging study. / Sone, Daichi; Imabayashi, Etsuko; Maikusa, Norihide; Okamura, Nobuyuki; Furumoto, Shozo; Kudo, Yukitsuka; Ogawa, Masayo; Takano, Harumasa; Yokoi, Yuma; Sakata, Masuhiro; Tsukamoto, Tadashi; Kato, Koichi; Matsuda, Hiroshi.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 9, 2017, p. 35-40.

Research output: Contribution to journal › Article › peer-review

Sone, D, Imabayashi, E, Maikusa, N, Okamura, N, Furumoto, S, Kudo, Y, Ogawa, M, Takano, H, Yokoi, Y, Sakata, M, Tsukamoto, T, Kato, K & Matsuda, H 2017, 'Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease: A combined positron emission tomography/magnetic resonance imaging study', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 9, pp. 35-40. https://doi.org/10.1016/j.dadm.2017.07.001

Sone D, Imabayashi E, Maikusa N, Okamura N, Furumoto S, Kudo Y et al. Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease: A combined positron emission tomography/magnetic resonance imaging study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2017;9:35-40. https://doi.org/10.1016/j.dadm.2017.07.001

Sone, Daichi ; Imabayashi, Etsuko ; Maikusa, Norihide ; Okamura, Nobuyuki ; Furumoto, Shozo ; Kudo, Yukitsuka ; Ogawa, Masayo ; Takano, Harumasa ; Yokoi, Yuma ; Sakata, Masuhiro ; Tsukamoto, Tadashi ; Kato, Koichi ; Matsuda, Hiroshi. / Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease : A combined positron emission tomography/magnetic resonance imaging study. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2017 ; Vol. 9. pp. 35-40.

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title = "Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease: A combined positron emission tomography/magnetic resonance imaging study",

abstract = "Introduction Molecular imaging and selective hippocampal subfield atrophy are a focus of recent Alzheimer's disease (AD) research. Here, we investigated correlations between molecular imaging and hippocampal subfields in early AD. Methods We investigated 18 patients with early AD and 18 healthy control subjects using 11C-Pittsburgh compound-B (PIB) positron emission tomography (PET) and 18F-THK5351 PET and automatic segmentation of hippocampal subfields with high-resolution T2-weighted magnetic resonance imaging. The PET images were normalized and underwent voxelwise regression analysis with each subregion volumes using SPM12. Results As for 18F-THK5351 PET, the bilateral perirhinal cortex volumes were significantly associated with the ipsilateral or bilateral temporal lobar uptakes, whereas hippocampal subfields showed no correlations. 11C-PIB PET showed relatively broad negative correlation with the right cornu ammonis 3 volumes. Discussion Regional tau deposition was correlated with extrahippocampal subregional atrophy and not with hippocampal subfields, possibly reflecting different underlying mechanisms of atrophy in early AD. Amyloid might be associated with right cornu ammonis 3 atrophy.",

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author = "Daichi Sone and Etsuko Imabayashi and Norihide Maikusa and Nobuyuki Okamura and Shozo Furumoto and Yukitsuka Kudo and Masayo Ogawa and Harumasa Takano and Yuma Yokoi and Masuhiro Sakata and Tadashi Tsukamoto and Koichi Kato and Hiroshi Matsuda",

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T1 - Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease

T2 - A combined positron emission tomography/magnetic resonance imaging study

AU - Sone, Daichi

AU - Imabayashi, Etsuko

AU - Maikusa, Norihide

AU - Okamura, Nobuyuki

AU - Furumoto, Shozo

AU - Kudo, Yukitsuka

AU - Ogawa, Masayo

AU - Takano, Harumasa

AU - Yokoi, Yuma

AU - Sakata, Masuhiro

AU - Tsukamoto, Tadashi

AU - Kato, Koichi

AU - Matsuda, Hiroshi

PY - 2017

Y1 - 2017

N2 - Introduction Molecular imaging and selective hippocampal subfield atrophy are a focus of recent Alzheimer's disease (AD) research. Here, we investigated correlations between molecular imaging and hippocampal subfields in early AD. Methods We investigated 18 patients with early AD and 18 healthy control subjects using 11C-Pittsburgh compound-B (PIB) positron emission tomography (PET) and 18F-THK5351 PET and automatic segmentation of hippocampal subfields with high-resolution T2-weighted magnetic resonance imaging. The PET images were normalized and underwent voxelwise regression analysis with each subregion volumes using SPM12. Results As for 18F-THK5351 PET, the bilateral perirhinal cortex volumes were significantly associated with the ipsilateral or bilateral temporal lobar uptakes, whereas hippocampal subfields showed no correlations. 11C-PIB PET showed relatively broad negative correlation with the right cornu ammonis 3 volumes. Discussion Regional tau deposition was correlated with extrahippocampal subregional atrophy and not with hippocampal subfields, possibly reflecting different underlying mechanisms of atrophy in early AD. Amyloid might be associated with right cornu ammonis 3 atrophy.

AB - Introduction Molecular imaging and selective hippocampal subfield atrophy are a focus of recent Alzheimer's disease (AD) research. Here, we investigated correlations between molecular imaging and hippocampal subfields in early AD. Methods We investigated 18 patients with early AD and 18 healthy control subjects using 11C-Pittsburgh compound-B (PIB) positron emission tomography (PET) and 18F-THK5351 PET and automatic segmentation of hippocampal subfields with high-resolution T2-weighted magnetic resonance imaging. The PET images were normalized and underwent voxelwise regression analysis with each subregion volumes using SPM12. Results As for 18F-THK5351 PET, the bilateral perirhinal cortex volumes were significantly associated with the ipsilateral or bilateral temporal lobar uptakes, whereas hippocampal subfields showed no correlations. 11C-PIB PET showed relatively broad negative correlation with the right cornu ammonis 3 volumes. Discussion Regional tau deposition was correlated with extrahippocampal subregional atrophy and not with hippocampal subfields, possibly reflecting different underlying mechanisms of atrophy in early AD. Amyloid might be associated with right cornu ammonis 3 atrophy.

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