Regional metabolism: Associations with dyscalculia in Alzheimer's disease

Nobutsugu Hirono, Etsuro Mori, Kazunari Ishii, Toru Imamura, Tatsuo Shimomura, Satoshi Tanimukai, Hiroaki Kazui, Mamoru Hashimoto, Hikari Yamashita, Masahiro Sasaki

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Objectives - The ability to calculate, which is an important aspect of social daily living, is commonly impaired in patients with Alzheimer's disease even early in the course of the disease. Dyscalculia is often accompanied by focal brain damage, and has been argued to be an independent sign localised around the left temporoparietal region. However, the region most responsible for dyscalculia in Alzheimer's disease has not been determined. The relation between calculation ability and regional cerebral glucose metabolism in Alzheimer's disease was therefore examined. Methods - The calculation ability, In 91 patients with probable Alzheimer's disease of minimal to moderate severity, was assessed using the arithmetic subtest of the Wechsler adult intelligence scale-revised and the performance correlated with regional cerebral glucose metabolism determined by 18F-fluorodeoxyglucose and PET. Results - Regional glucose metabolism in the left inferior parietal lobule and in the left inferior temporal gyrus was significantly correlated with the calculation performance irrespective of age, sex, education, and severity of disease. Conclusions - The results suggest that dysfunction of the left inferior parietal lobule and the left inferior temporal gyrus plays an important part in producing dyscalculia in patients with Alzheimer's disease.

Original languageEnglish
Pages (from-to)913-916
Number of pages4
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number6
Publication statusPublished - 1998
Externally publishedYes


  • Alzheimer's disease
  • Calculation
  • Left inferior parietal lobule

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health


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