Regional hypometabolism related to language disturbance in Alzheimer's disease

Nobutsugu Hirono, Etsuro Mori, Kazunari Ishii, Yoshitaka Ikejiri, Toru Imamura, Tatsuo Shimomura, Manabu Ikeda, Hikari Yamashita, Yoko Takatsuki, Masahiro Sasaki

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


To elucidate the nature of language disturbance in Alzheimer's disease (AD) and the cerebral area involved in it, we studied 65 AD patients with the Western Aphasia Battery (WAB) and with 18F-fluorodeoxyglucose and positron emission tomography. Partial correlations were evaluated between the Aphasia Quotient of WAB and regional cerebral glucose metabolism normalized by the mean metabolic rate in the bilateral primary sensorimotor areas after controlling age, sex, education and severity of illness. Language disturbance in AD is accounted for by deficits in the semantic processing of language and is related to glucose hypometabolism in the inferior temporal gyrus and inferior parietal lobule, especially in the dominant side. These results offer further evidence suggesting that the lexico-semantic processing system is mediated in these regions.

Original languageEnglish
Pages (from-to)68-73
Number of pages6
JournalDementia and geriatric cognitive disorders
Issue number2
Publication statusPublished - 1998 Jan 1


  • Alzheimer's disease
  • Language disorders
  • Positron emission tomography

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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