Regional differences of type II collagen synthesis in the human temporomandibular joint disc: Immunolocalization study of carboxy-terminal type II procollagen peptide (chondrocalcin)

Toshirou Kondoh, Yoshiki Hamada, Mitsuyoshi Iino, Tetsu Takahashi, Toshiyuki Kikuchi, Kyousuke Fujikawa, Kannichi Seto

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The purpose of this study was to determine the regional differences of distribution of the carboxy-terminal type II procollagen peptide (pCOL-II-C; chondrocalcin) as markers of cartilaginous expression in the human temporomandibular joint (TMJ) disc. Twelve human TMJ discs without morphologic abnormalities were obtained from 12 fresh cadavers. All specimens were analysed for pCOL-II-C expression using polyclonal rabbit anti-human pCOL-II-C antibody in avidin-biotin-peroxidase complex staining. The results were demonstrated that the percentage of pCOL-II-C immunoreactive disc cells was significantly higher in the outer part (the articular surfaces) than in the inner part (the deep central areas) of the disc. These findings suggest that the tissue heterogeneity of cartilaginous expression reflects the functional demands of the remodelling process in the human TMJ disc.

Original languageEnglish
Pages (from-to)621-625
Number of pages5
JournalArchives of Oral Biology
Volume48
Issue number9
DOIs
Publication statusPublished - 2003 Sep 1
Externally publishedYes

Keywords

  • Carboxy-terminal type II procollagen peptide
  • Chondrocalcin
  • Temporomandibular joint disc
  • Type II collagen

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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