Regional Cerebral Metabolic Rate for Glucose and Cerebrospinal Fluid Monoamine Metabolites in Subacute Sclerosing Panencephalitis

Kazuhiko Yanai, Shigeaki Miyabayashi, Kazuie Ilnuma, Keiya Tada, Hiroshi Fukuda, Masatoshi Ito, Taiju Matsuzawa

Research output: Contribution to journalArticlepeer-review

Abstract

Regional Cerebral Metabolic Rate for Glucose and Cerebrospinal Fluid Monoamine Metabolites in Subacute Sclerosing Panencephalitis. Tohoku J. exp. Med., 1987, 152 (2), 103-109-Regional cerebral metabolic rate for glucose (rCMRglu) and cerebrospinal fluid monoamine metabolites were measured in two cases of subacute sclerosing panencephalitis (SSPE) with different clinical courses. A marked decrease in rCMRglu was found in the cortical gray matter of a patient with rapidly developing SSPE (3.6-4.2 mg/100 g brain tissue/min). However, the rCMRglu was preserved in the caudate and lenticular nuclei of the patient (7.7 mg/ 100 g/min). The rCMRglu in a patient with slowly developing SSPE revealed patterns and values similar to those of the control. Cerebrospinal fluid monoamine metabolites; homovanilic acid and 5-hydroxyindoleacetic acid, were decreased in both rapidly and slowly developing SSPE. These data indicated that rCMRglu correlated better with the neurological and psychological status and that dopaminergic and serotonergic abnormalities have been implicated in pathophysiology of SSPE.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
Journalthe tohoku journal of experimental medicine
Volume152
Issue number2
DOIs
Publication statusPublished - 1987

Keywords

  • cerebrospinal fluid
  • glucose metabolism
  • monoamine metabolites
  • positron emission CT
  • subacute sclerosing panencephalitis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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