Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: A comparative study using positron emission tomography

Toru Imamura, Kazunari Ishii, Masahiro Sasaki, Hajime Kitagaki, Shigeru Yamaji, Nobutsugu Hirono, Tatsuo Shimomura, Mamoru Hashimoto, Satoshi Tanimukai, Hiroaki Kazui, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

116 Citations (Scopus)

Abstract

Regional cerebral metabolic rate of glucose (rCMRglc) was studied in 19 patients with a clinical diagnosis of dementia with Lewy bodies (DLB) and 19 patients with a clinical diagnosis of Alzheimer's disease (AD), using [18F]fluorodeoxyglucose ([18F]FDG) and positron emission tomography (PET). The two groups were matched with age, gender, disease duration and severity of cognitive disturbances. In 'dementia with Lewy bodies' (DLB) patients, when compared with AD patients, significant rCMRglc decreases were distributed in the temporo-parieto-occipital association cortices and the cerebellar hemispheres. In contrast; the medial temporal and cingulate rCMRglc were significantly lower in AD patients than those in DLB patients. These different regional emphases of glucose hypometabolism are consistent with the pathological and neurochemical differences between DLB and AD and explain the different clinical features of the two diseases.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalNeuroscience Letters
Volume235
Issue number1-2
DOIs
Publication statusPublished - 1997 Oct 10

Keywords

  • Alzheimer's disease
  • Cerebellum
  • Dementia with Lewy bodies
  • Limbic area
  • Occipital lobe
  • Positron emission tomography
  • [F]Fluorodeoxyglucose

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: A comparative study using positron emission tomography'. Together they form a unique fingerprint.

Cite this