Regional Brain Activity and Performance During Car-Driving Under Side Effects of Psychoactive Drugs

Manabu Tashiro, M. D. Masud Mehedi, Myeonggi Jeong, Yumiko Sakurada, Hideki Mochizuki, Etsuo Horikawa, Motohisa Kato, Masahiro Maruyama, Nobuyuki Okamura, Shoichi Watanuki, Hiroyuki Arai, Masatoshi Itoh, Kazuhiko Yanai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


Sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated cardriving task following oral administration of dchlorpheniramine using positron emission tomography (PET) and [15O]H2O. Healthy volunteers drove a car in a simulated environment following oral administration of a sedative antihistamine, d-chlorpheniramine, or placebo. Their rCBF was measured in the conditions of resting, active driving, and passive driving. Performance evaluation revealed that the number of lane deviations significantly increased in the dchlorpheniramine condition (p<0.01). Subjective sleepiness was not significantly different between the two drug conditions. The regions of diminished brain responses were detected following d-chlorpheniramine treatment in the parietal, temporal and visual cortices and in the cerebellum. These results suggest that d-chlorpheniramine tends to suppress visuo-spatial cognition and visuo-motor coordination even when the subjects do not recognize subjective feeling of sedation.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
Number of pages3
Publication statusPublished - 2009
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 2008 Dec 32008 Dec 6

Publication series

NameIFMBE Proceedings
ISSN (Print)1680-0737


Other13th International Conference on Biomedical Engineering, ICBME 2008


  • Positron emission tomography (PET)
  • driving performance
  • regional cerebral blood flow (rCBF)
  • sedative antihistamine

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering


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