Region-specific growth restriction of brain following preterm birth

Sachiko Iwata, Reiji Katayama, Masahiro Kinoshita, Mamoru Saikusa, Yuko Araki, Sachio Takashima, Toshi Abe, Osuke Iwata

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12 Citations (Scopus)


Regional brain sizes of very-preterm infants at term-equivalent age differ from those of term-born peers, which have been linked with later cognitive impairments. However, dependence of regional brain volume loss on gestational age has not been studied in detail. To investigate the spatial pattern of brain growth in neonates without destructive brain lesions, head MRI of 189 neonates with a wide range of gestational age (24-42 weeks gestation) was assessed using simple metrics measurements. Dependence of MRI findings on gestational age at birth (Age birth) and the corrected age at MRI scan (Age MRI) were assessed. The head circumference was positively correlated with Age MRI, but not Age birth. The bi-parietal width, deep grey matter area and the trans-cerebellar diameter were positively correlated with both Age birth and Age MRI. The callosal thickness (positive), atrial width of lateral ventricle (negative) and the inter-hemispheric distance (negative) were exclusively correlated with Age birth. The callosal thickness and cerebral/cerebellar transverse diameters showed predominant dependence on Age birth over Age MRI, suggesting that brain growth after preterm-birth was considerably restricted or even became negligible compared with that in utero. Such growth restriction after preterm birth may extensively affect relatively more matured infants, considering the linear relationships observed between brain sizes and Age birth.

Original languageEnglish
Article number33995
JournalScientific reports
Publication statusPublished - 2016 Sept 23
Externally publishedYes

ASJC Scopus subject areas

  • General


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