Regio- and stereoselective hydroamidation of 1-alkynylphosphine sulfides catalyzed by cesium base

Azusa Kondoh, Hideki Yorimitsu, Koichiro Oshima

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

(Chemical Equation Presented) Regio- and stereoselective hydroamidation of 1-alkynylphosphine sulfides proceeds in the presence of cesium carbonate to provide (E)-2-amino-1-thiophosphinyl-1-alkenes. Asymmetric hydrogenation of the adducts catalyzed by an iridium complex followed by desulfidation yields 2-amino-1-phosphinoalkanes, which offers a new approach to chiral N,P-ligands that will potentially serve as ligands in asymmetric reactions.

Original languageEnglish
Pages (from-to)3093-3095
Number of pages3
JournalOrganic letters
Volume10
Issue number14
DOIs
Publication statusPublished - 2008 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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