Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents

Yoshinori Yamamoto, Naoki Asao, Masaki Meguro, Naofumi Tsukada, Hisao Nemoto, Naoki Sadayori, J. Gerald Wilson, Hiroyuki Nakamura

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Amide cuprate reagents attack the less hindered carbon atom of epoxides to give 1,2-amino alcohols in good yields; this procedure is applied to the synthesis of an aziridine alcohol bearing a carborane framework which is a potentially useful 10B carrier for boron neutron capture therapy.

Original languageEnglish
Pages (from-to)1201-1203
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number15
DOIs
Publication statusPublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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