Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents

Yoshinori Yamamoto; Naoki Asao; Masaki Meguro; Naofumi Tsukada; Hisao Nemoto; Naoki Sadayori; J. Gerald Wilson; Hiroyuki Nakamura

doi:10.1039/C39930001201

Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents

Yoshinori Yamamoto, Naoki Asao, Masaki Meguro, Naofumi Tsukada, Hisao Nemoto, Naoki Sadayori, J. Gerald Wilson, Hiroyuki Nakamura

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Amide cuprate reagents attack the less hindered carbon atom of epoxides to give 1,2-amino alcohols in good yields; this procedure is applied to the synthesis of an aziridine alcohol bearing a carborane framework which is a potentially useful ¹⁰B carrier for boron neutron capture therapy.

Original language	English
Pages (from-to)	1201-1203
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	15
DOIs	https://doi.org/10.1039/C39930001201
Publication status	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

Access to Document

10.1039/C39930001201

Cite this

@article{4502d89d65d94fada30870cd9716b018,

title = "Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents",

abstract = "Amide cuprate reagents attack the less hindered carbon atom of epoxides to give 1,2-amino alcohols in good yields; this procedure is applied to the synthesis of an aziridine alcohol bearing a carborane framework which is a potentially useful 10B carrier for boron neutron capture therapy.",

author = "Yoshinori Yamamoto and Naoki Asao and Masaki Meguro and Naofumi Tsukada and Hisao Nemoto and Naoki Sadayori and Wilson, {J. Gerald} and Hiroyuki Nakamura",

year = "1993",

doi = "10.1039/C39930001201",

language = "English",

pages = "1201--1203",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "15",

}

TY - JOUR

T1 - Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents

AU - Yamamoto, Yoshinori

AU - Asao, Naoki

AU - Meguro, Masaki

AU - Tsukada, Naofumi

AU - Nemoto, Hisao

AU - Sadayori, Naoki

AU - Wilson, J. Gerald

AU - Nakamura, Hiroyuki

PY - 1993

Y1 - 1993

N2 - Amide cuprate reagents attack the less hindered carbon atom of epoxides to give 1,2-amino alcohols in good yields; this procedure is applied to the synthesis of an aziridine alcohol bearing a carborane framework which is a potentially useful 10B carrier for boron neutron capture therapy.

AB - Amide cuprate reagents attack the less hindered carbon atom of epoxides to give 1,2-amino alcohols in good yields; this procedure is applied to the synthesis of an aziridine alcohol bearing a carborane framework which is a potentially useful 10B carrier for boron neutron capture therapy.

UR - http://www.scopus.com/inward/record.url?scp=37049082911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37049082911&partnerID=8YFLogxK

U2 - 10.1039/C39930001201

DO - 10.1039/C39930001201

M3 - Article

AN - SCOPUS:37049082911

SP - 1201

EP - 1203

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 15

ER -

Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this