Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents

Yoshinori Yamamoto, Naoki Asao, Masaki Meguro, Naofumi Tsukada, Hisao Nemoto, Naoki Sadayori, J. Gerald Wilson, Hiroyuki Nakamura

    Research output: Contribution to journalArticlepeer-review

    63 Citations (Scopus)

    Abstract

    Amide cuprate reagents attack the less hindered carbon atom of epoxides to give 1,2-amino alcohols in good yields; this procedure is applied to the synthesis of an aziridine alcohol bearing a carborane framework which is a potentially useful 10B carrier for boron neutron capture therapy.

    Original languageEnglish
    Pages (from-to)1201-1203
    Number of pages3
    JournalJournal of the Chemical Society, Chemical Communications
    Issue number15
    DOIs
    Publication statusPublished - 1993 Dec 1

    ASJC Scopus subject areas

    • Molecular Medicine

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