Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents

Yoshinori Yamamoto; Naoki Asao; Masaki Meguro; Naofumi Tsukada; Hisao Nemoto; Naoki Sadayori; J. Gerald Wilson; Hiroyuki Nakamura

doi:10.1039/C39930001201

Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents

Yoshinori Yamamoto, Naoki Asao, Masaki Meguro, Naofumi Tsukada, Hisao Nemoto, Naoki Sadayori, J. Gerald Wilson, Hiroyuki Nakamura

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Amide cuprate reagents attack the less hindered carbon atom of epoxides to give 1,2-amino alcohols in good yields; this procedure is applied to the synthesis of an aziridine alcohol bearing a carborane framework which is a potentially useful ¹⁰B carrier for boron neutron capture therapy.

Original language	English
Pages (from-to)	1201-1203
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	15
DOIs	https://doi.org/10.1039/C39930001201
Publication status	Published - 1993

ASJC Scopus subject areas

Molecular Medicine

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Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents. / Yamamoto, Yoshinori; Asao, Naoki; Meguro, Masaki; Tsukada, Naofumi; Nemoto, Hisao; Sadayori, Naoki; Wilson, J. Gerald; Nakamura, Hiroyuki.

In: Journal of the Chemical Society, Chemical Communications, No. 15, 1993, p. 1201-1203.

Research output: Contribution to journal › Article › peer-review

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abstract = "Amide cuprate reagents attack the less hindered carbon atom of epoxides to give 1,2-amino alcohols in good yields; this procedure is applied to the synthesis of an aziridine alcohol bearing a carborane framework which is a potentially useful 10B carrier for boron neutron capture therapy.",

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AU - Yamamoto, Yoshinori

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AU - Meguro, Masaki

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AU - Nemoto, Hisao

AU - Sadayori, Naoki

AU - Wilson, J. Gerald

AU - Nakamura, Hiroyuki

PY - 1993

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AB - Amide cuprate reagents attack the less hindered carbon atom of epoxides to give 1,2-amino alcohols in good yields; this procedure is applied to the synthesis of an aziridine alcohol bearing a carborane framework which is a potentially useful 10B carrier for boron neutron capture therapy.

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Regio- and stereo-selective ring opening of epoxides with amide cuprate reagents

Abstract

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