REG Iα protein expression in Barrett's esophagus

Daisuke Chinuki, Yuji Amano, Shunji Ishihara, Nobuyuki Moriyama, Norihisa Ishimura, Hideaki Kazumori, Yasunori Kadowaki, Shin Takasawa, Hiroshi Okamoto, Yoshikazu Kinoshita

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Background and Aim: Accelerated cellular proliferation in Barrett's esophagus has been implicated in Barrett's elongation and malignant transformation. Therefore, growth factors may play important roles in the pathophysiology of Barrett's esophagus. Regenerating gene (REG), an epithelial growth factor, has been reported to link mucosal inflammation and subsequent carcinogenesis in the gastrointestinal tract. The aim of this study was to investigate whether REG is expressed in Barrett's esophagus and to elucidate the relationship between REG protein expression and clinicopathological factors of Barrett's esophagus. Methods: Between July 2003 and June 2004, 266 patients with endoscopically and histologically proven Barrett's esophagus were enrolled in this study. Before endoscopic examination, all participants were requested to answer structured questionnaires on gastroesophageal reflux symptoms and drugs usage. Mucin phenotype, cyclooxygenase-2 expression, cellular proliferation, apoptosis and REG Iα protein expression were investigated in the biopsy samples taken from Barrett's esophagus. Clinicopathological factors that correlated with REG Iα protein expression in patients with Barrett's esophagus were evaluated using multivariate logistic regression analysis. Results: REG Iα protein expression was observed in 48 (18.0%) of 266 patients with Barrett's esophagus by immunohistochemistry. Newly developed squamous re-epithelialization of Barrett's esophagus at biopsy sites, presence of hiatal hernia and aging were shown to correlate with REG Iα protein expression. Conclusions: The present study is the first to show REG expression in Barrett's esophagus. Expression of REG Iα was more frequently observed in patients who showed squamous re-epithelialization of Barrett's esophagus at biopsy sites.

Original languageEnglish
Pages (from-to)296-302
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number2
Publication statusPublished - 2008 Feb


  • Barrett's esophagus
  • Hiatus hernia
  • REG Iα
  • Squamous re-epithelialization

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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