Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia

Satoshi Horino, Takeshi Rikiishi, Hidetaka Niizuma, Hiroshi Abe, Yuko Watanabe, Masaei Onuma, Yoshiyuki Hoshi, Yoji Sasahara, Miyako Yoshinari, Takuro Kazama, Yutaka Hayashi, Satoru Kumaki, Shigeru Tsuchiya

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7 Citations (Scopus)

Abstract

Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during early intensive phase of chemotherapy for ALL. She underwent splenectomy because thrombocytopenia had persisted even after treatment with intravenous immunoglobulin (IVIG), steroids, vincristine, rituximab, and anti-D antibody. After splenectomy, her platelet count had recovered, and maintenance therapy could be resumed with a support of IVIG. To our knowledge, this is the first child case of chronic ITP during chemotherapy for ALL and splenectomy was effective in this patient.

Original languageEnglish
Pages (from-to)483-485
Number of pages3
JournalInternational journal of hematology
Volume90
Issue number4
DOIs
Publication statusPublished - 2009 Oct 13

Keywords

  • Acute lymphoblastic leukemia
  • GP IIb/IIIa
  • Immune thrombocytopenic purpura

ASJC Scopus subject areas

  • Hematology

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    Horino, S., Rikiishi, T., Niizuma, H., Abe, H., Watanabe, Y., Onuma, M., Hoshi, Y., Sasahara, Y., Yoshinari, M., Kazama, T., Hayashi, Y., Kumaki, S., & Tsuchiya, S. (2009). Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia. International journal of hematology, 90(4), 483-485. https://doi.org/10.1007/s12185-009-0424-0