Reflection of 18F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation

Shinji Kito; Hirofumi Koga; Masaaki Kodama; Noriaki Yamamoto; Shinya Kokuryo; Manabu Habu; Kou Matsuo; Takanobu Nishino; Kohzoh Kubota; Kosuke Muraoka; Masafumi Oda; Nao Wakasugi-Sato; Shinobu Matsumoto-Takeda; Yuji Seta; Tatsurou Tanaka; Ikuya Miyamoto; Yoshihiro Yamashita; Chiaki Kitamura; Keisuke Nakashima; Tetsu Takahashi; Kazuhiro Tominaga; Yasuhiro Morimoto

doi:10.1016/j.oooo.2012.05.027

Reflection of ¹⁸F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation

Shinji Kito, Hirofumi Koga, Masaaki Kodama, Noriaki Yamamoto, Shinya Kokuryo, Manabu Habu, Kou Matsuo, Takanobu Nishino, Kohzoh Kubota, Kosuke Muraoka, Masafumi Oda, Nao Wakasugi-Sato, Shinobu Matsumoto-Takeda, Yuji Seta, Tatsurou Tanaka, Ikuya Miyamoto, Yoshihiro Yamashita, Chiaki Kitamura, Keisuke Nakashima, Tetsu TakahashiKazuhiro Tominaga, Yasuhiro Morimoto

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Objectives: To elucidate whether fluorine-18-labeled (¹⁸F) fluoro-2-deoxy-d-glucose (FDG) accumulation can reflect the extent of periodontal inflammation, periapical inflammation, or dental caries. Study Design: ¹⁸F-FDG accumulations on positron emission tomography (PET)-computed tomography (CT) were retrospectively compared with the size of the bone resorption areas caused by periodontal inflammation, periapical inflammation, or dental caries on panoramic radiographs, CT, and magnetic resonance imaging (MRI) in 44 subjects. Results: A significant correlation was found between the size of the bone resorption area caused by periodontal (r = 0.595, P <.01) or periapical (r = 0.560, P <.01) inflammation and the highest standardized uptake value (SUVmax) of ¹⁸F-FDG accumulation. A significant correlation was found between the periodontal (r = 0.622, P <.01) or periapical (r = 0.394, P <.01) inflammatory findings on MRI and the SUVmax of ¹⁸F-FDG accumulation. The SUVmax of ¹⁸F-FDG around most teeth with caries was under 1.5. Conclusions: ¹⁸F-FDG accumulation reflects the extent of dental inflammation, not dental caries.

Original language	English
Pages (from-to)	e62-e69
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	114
Issue number	6
DOIs	https://doi.org/10.1016/j.oooo.2012.05.027
Publication status	Published - 2012 Dec
Externally published	Yes

ASJC Scopus subject areas

Surgery
Oral Surgery
Pathology and Forensic Medicine
Dentistry (miscellaneous)
Radiology Nuclear Medicine and imaging

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Kito, S., Koga, H., Kodama, M., Yamamoto, N., Kokuryo, S., Habu, M., Matsuo, K., Nishino, T., Kubota, K., Muraoka, K., Oda, M., Wakasugi-Sato, N., Matsumoto-Takeda, S., Seta, Y., Tanaka, T., Miyamoto, I., Yamashita, Y., Kitamura, C., Nakashima, K., ... Morimoto, Y. (2012). Reflection of ¹⁸F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 114(6), e62-e69. https://doi.org/10.1016/j.oooo.2012.05.027

Reflection of ¹⁸F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation. / Kito, Shinji; Koga, Hirofumi; Kodama, Masaaki; Yamamoto, Noriaki; Kokuryo, Shinya; Habu, Manabu; Matsuo, Kou; Nishino, Takanobu; Kubota, Kohzoh; Muraoka, Kosuke; Oda, Masafumi; Wakasugi-Sato, Nao; Matsumoto-Takeda, Shinobu; Seta, Yuji; Tanaka, Tatsurou; Miyamoto, Ikuya; Yamashita, Yoshihiro; Kitamura, Chiaki; Nakashima, Keisuke; Takahashi, Tetsu; Tominaga, Kazuhiro; Morimoto, Yasuhiro.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 114, No. 6, 12.2012, p. e62-e69.

Research output: Contribution to journal › Article › peer-review

Kito, S, Koga, H, Kodama, M, Yamamoto, N, Kokuryo, S, Habu, M, Matsuo, K, Nishino, T, Kubota, K, Muraoka, K, Oda, M, Wakasugi-Sato, N, Matsumoto-Takeda, S, Seta, Y, Tanaka, T, Miyamoto, I, Yamashita, Y, Kitamura, C, Nakashima, K, Takahashi, T, Tominaga, K & Morimoto, Y 2012, 'Reflection of ¹⁸F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 114, no. 6, pp. e62-e69. https://doi.org/10.1016/j.oooo.2012.05.027

Kito, Shinji ; Koga, Hirofumi ; Kodama, Masaaki ; Yamamoto, Noriaki ; Kokuryo, Shinya ; Habu, Manabu ; Matsuo, Kou ; Nishino, Takanobu ; Kubota, Kohzoh ; Muraoka, Kosuke ; Oda, Masafumi ; Wakasugi-Sato, Nao ; Matsumoto-Takeda, Shinobu ; Seta, Yuji ; Tanaka, Tatsurou ; Miyamoto, Ikuya ; Yamashita, Yoshihiro ; Kitamura, Chiaki ; Nakashima, Keisuke ; Takahashi, Tetsu ; Tominaga, Kazuhiro ; Morimoto, Yasuhiro. / Reflection of ¹⁸F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2012 ; Vol. 114, No. 6. pp. e62-e69.

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title = "Reflection of 18F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation",

abstract = "Objectives: To elucidate whether fluorine-18-labeled (18F) fluoro-2-deoxy-d-glucose (FDG) accumulation can reflect the extent of periodontal inflammation, periapical inflammation, or dental caries. Study Design: 18F-FDG accumulations on positron emission tomography (PET)-computed tomography (CT) were retrospectively compared with the size of the bone resorption areas caused by periodontal inflammation, periapical inflammation, or dental caries on panoramic radiographs, CT, and magnetic resonance imaging (MRI) in 44 subjects. Results: A significant correlation was found between the size of the bone resorption area caused by periodontal (r = 0.595, P <.01) or periapical (r = 0.560, P <.01) inflammation and the highest standardized uptake value (SUVmax) of 18F-FDG accumulation. A significant correlation was found between the periodontal (r = 0.622, P <.01) or periapical (r = 0.394, P <.01) inflammatory findings on MRI and the SUVmax of 18F-FDG accumulation. The SUVmax of 18F-FDG around most teeth with caries was under 1.5. Conclusions: 18F-FDG accumulation reflects the extent of dental inflammation, not dental caries.",

author = "Shinji Kito and Hirofumi Koga and Masaaki Kodama and Noriaki Yamamoto and Shinya Kokuryo and Manabu Habu and Kou Matsuo and Takanobu Nishino and Kohzoh Kubota and Kosuke Muraoka and Masafumi Oda and Nao Wakasugi-Sato and Shinobu Matsumoto-Takeda and Yuji Seta and Tatsurou Tanaka and Ikuya Miyamoto and Yoshihiro Yamashita and Chiaki Kitamura and Keisuke Nakashima and Tetsu Takahashi and Kazuhiro Tominaga and Yasuhiro Morimoto",

year = "2012",

month = dec,

doi = "10.1016/j.oooo.2012.05.027",

language = "English",

volume = "114",

pages = "e62--e69",

journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",

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T1 - Reflection of 18F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation

AU - Kito, Shinji

AU - Koga, Hirofumi

AU - Kodama, Masaaki

AU - Yamamoto, Noriaki

AU - Kokuryo, Shinya

AU - Habu, Manabu

AU - Matsuo, Kou

AU - Nishino, Takanobu

AU - Kubota, Kohzoh

AU - Muraoka, Kosuke

AU - Oda, Masafumi

AU - Wakasugi-Sato, Nao

AU - Matsumoto-Takeda, Shinobu

AU - Seta, Yuji

AU - Tanaka, Tatsurou

AU - Miyamoto, Ikuya

AU - Yamashita, Yoshihiro

AU - Kitamura, Chiaki

AU - Nakashima, Keisuke

AU - Takahashi, Tetsu

AU - Tominaga, Kazuhiro

AU - Morimoto, Yasuhiro

PY - 2012/12

Y1 - 2012/12

N2 - Objectives: To elucidate whether fluorine-18-labeled (18F) fluoro-2-deoxy-d-glucose (FDG) accumulation can reflect the extent of periodontal inflammation, periapical inflammation, or dental caries. Study Design: 18F-FDG accumulations on positron emission tomography (PET)-computed tomography (CT) were retrospectively compared with the size of the bone resorption areas caused by periodontal inflammation, periapical inflammation, or dental caries on panoramic radiographs, CT, and magnetic resonance imaging (MRI) in 44 subjects. Results: A significant correlation was found between the size of the bone resorption area caused by periodontal (r = 0.595, P <.01) or periapical (r = 0.560, P <.01) inflammation and the highest standardized uptake value (SUVmax) of 18F-FDG accumulation. A significant correlation was found between the periodontal (r = 0.622, P <.01) or periapical (r = 0.394, P <.01) inflammatory findings on MRI and the SUVmax of 18F-FDG accumulation. The SUVmax of 18F-FDG around most teeth with caries was under 1.5. Conclusions: 18F-FDG accumulation reflects the extent of dental inflammation, not dental caries.

AB - Objectives: To elucidate whether fluorine-18-labeled (18F) fluoro-2-deoxy-d-glucose (FDG) accumulation can reflect the extent of periodontal inflammation, periapical inflammation, or dental caries. Study Design: 18F-FDG accumulations on positron emission tomography (PET)-computed tomography (CT) were retrospectively compared with the size of the bone resorption areas caused by periodontal inflammation, periapical inflammation, or dental caries on panoramic radiographs, CT, and magnetic resonance imaging (MRI) in 44 subjects. Results: A significant correlation was found between the size of the bone resorption area caused by periodontal (r = 0.595, P <.01) or periapical (r = 0.560, P <.01) inflammation and the highest standardized uptake value (SUVmax) of 18F-FDG accumulation. A significant correlation was found between the periodontal (r = 0.622, P <.01) or periapical (r = 0.394, P <.01) inflammatory findings on MRI and the SUVmax of 18F-FDG accumulation. The SUVmax of 18F-FDG around most teeth with caries was under 1.5. Conclusions: 18F-FDG accumulation reflects the extent of dental inflammation, not dental caries.

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