Reflection of 18F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation

Shinji Kito, Hirofumi Koga, Masaaki Kodama, Noriaki Yamamoto, Shinya Kokuryo, Manabu Habu, Kou Matsuo, Takanobu Nishino, Kohzoh Kubota, Kosuke Muraoka, Masafumi Oda, Nao Wakasugi-Sato, Shinobu Matsumoto-Takeda, Yuji Seta, Tatsurou Tanaka, Ikuya Miyamoto, Yoshihiro Yamashita, Chiaki Kitamura, Keisuke Nakashima, Tetsu TakahashiKazuhiro Tominaga, Yasuhiro Morimoto

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Objectives: To elucidate whether fluorine-18-labeled (18F) fluoro-2-deoxy-d-glucose (FDG) accumulation can reflect the extent of periodontal inflammation, periapical inflammation, or dental caries. Study Design: 18F-FDG accumulations on positron emission tomography (PET)-computed tomography (CT) were retrospectively compared with the size of the bone resorption areas caused by periodontal inflammation, periapical inflammation, or dental caries on panoramic radiographs, CT, and magnetic resonance imaging (MRI) in 44 subjects. Results: A significant correlation was found between the size of the bone resorption area caused by periodontal (r = 0.595, P <.01) or periapical (r = 0.560, P <.01) inflammation and the highest standardized uptake value (SUVmax) of 18F-FDG accumulation. A significant correlation was found between the periodontal (r = 0.622, P <.01) or periapical (r = 0.394, P <.01) inflammatory findings on MRI and the SUVmax of 18F-FDG accumulation. The SUVmax of 18F-FDG around most teeth with caries was under 1.5. Conclusions: 18F-FDG accumulation reflects the extent of dental inflammation, not dental caries.

Original languageEnglish
Pages (from-to)e62-e69
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume114
Issue number6
DOIs
Publication statusPublished - 2012 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

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