Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat

W. R. Zhang, T. Hayashi, J. M. Wang, C. Sasaki, K. Sakai, H. Warita, Y. Shiro, H. Suenaga, H. Ohmae, S. Tsuji, T. Itoh, O. Nishimura, H. Nagasaki, K. Abe

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Infarct volume and immunoreactivities for trkB and trkC in rat brain were compared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 μg/250 g animal). Treatment of rat brain with topical application of NT-3 significantly reduced infarct volume (P=0.02) and trkB and trkC inductions. These data suggest that NT-3 reduced the ischemic injury along with the reduction of trkB and trkC inductions. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalNeuroscience Letters
Volume276
Issue number3
DOIs
Publication statusPublished - 1999 Dec 10
Externally publishedYes

Keywords

  • Ischemia
  • Middle cerebral artery occlusion
  • Neurotrophin-3
  • Tyrosine kinase B
  • Tyrosine kinase C

ASJC Scopus subject areas

  • Neuroscience(all)

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