TY - JOUR
T1 - Reduction of Oxidized Low-Density Lipoprotein by the Long-Term Use of Vitamin E-Coated Dialyzers in Hemodialysis Patients
AU - Hara, Taiga
AU - Takahashi, Norihiro
AU - Kiyomoto, Hideyasu
AU - Aki, Yasuharu
AU - Fujioka, Hiroshi
AU - Shokoji, Takatomi
AU - Matsubara, Keisuke
AU - Moriwaki, Kumiko
AU - Kondo, Naoki
AU - Kiyomoto, Kayo
AU - Hirohata, Mamoru
AU - Ishizu, Tsutomu
AU - Akiyama, Kenji
AU - Nishiyama, Akira
AU - Ohmori, Koji
AU - Kohno, Masakazu
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/4
Y1 - 2004/4
N2 - Purpose. Recently, oxidative stress and oxidized low-density lipoprotein (Ox-LDL) have been suggested as causative factors for the progression of arteriosclerosis. Antioxidants such as vitamin E are known to reduce oxidative stress. Therefore, we evaluated the oxidative stress exhibited by different dialysis membranes and clarified the possibility of the effectiveness of the antioxidative action of a vitamin E-coated dialyzer, the Excebrane™ (EX), in patients receiving maintenance hemodialysis (HD). Methods. We compared the serum levels of Ox-LDL among four groups of subjects: healthy volunteers, patients with mild or moderate renal failure, patients receiving continuous ambulatory peritoneal dialysis, and patients undergoing HD. In order to evaluate the newly developed antioxidative EX membrane, we measured serum Ox-LDL in patients receiving HD with conventional dialyzers who were then switched to dialyzers equipped with the EX membrane. Data were compared in terms of time-course changes following the switch to the new dialyzer to evaluate the effectiveness of its antioxidative action. Results. The highest levels of Ox-LDL were obtained for patients receiving HD. The values of Ox-LDL in the EX group were significantly lower than those in the conventional HD group. In addition, serum levels of Ox-LDL dropped significantly after the switch from the conventional dialyzer to the EX dialyzer. Conclusions. As emphasized in the present study, improvement of the HD process, especially the dialysis membrane system in terms of reduction in oxidative stress, may be important for the prevention of arteriosclerosis progression.
AB - Purpose. Recently, oxidative stress and oxidized low-density lipoprotein (Ox-LDL) have been suggested as causative factors for the progression of arteriosclerosis. Antioxidants such as vitamin E are known to reduce oxidative stress. Therefore, we evaluated the oxidative stress exhibited by different dialysis membranes and clarified the possibility of the effectiveness of the antioxidative action of a vitamin E-coated dialyzer, the Excebrane™ (EX), in patients receiving maintenance hemodialysis (HD). Methods. We compared the serum levels of Ox-LDL among four groups of subjects: healthy volunteers, patients with mild or moderate renal failure, patients receiving continuous ambulatory peritoneal dialysis, and patients undergoing HD. In order to evaluate the newly developed antioxidative EX membrane, we measured serum Ox-LDL in patients receiving HD with conventional dialyzers who were then switched to dialyzers equipped with the EX membrane. Data were compared in terms of time-course changes following the switch to the new dialyzer to evaluate the effectiveness of its antioxidative action. Results. The highest levels of Ox-LDL were obtained for patients receiving HD. The values of Ox-LDL in the EX group were significantly lower than those in the conventional HD group. In addition, serum levels of Ox-LDL dropped significantly after the switch from the conventional dialyzer to the EX dialyzer. Conclusions. As emphasized in the present study, improvement of the HD process, especially the dialysis membrane system in terms of reduction in oxidative stress, may be important for the prevention of arteriosclerosis progression.
UR - http://www.scopus.com/inward/record.url?scp=11144353598&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144353598&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:11144353598
VL - 33
SP - 197
EP - 207
JO - Dialysis and Transplantation
JF - Dialysis and Transplantation
SN - 0090-2934
IS - 4
ER -