Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease

Kazunari Ishii, Masahiro Sasaki, Hajime Kitagaki, Shigeru Yamaji, Setsu Sakamoto, Kant Matsuda, Etsuro Mori

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136 Citations (Scopus)

Abstract

Although regional cerebral metabolism and blood flow in Alzheimer's disease (AD) have been studied extensively with PET and SPECT, few reports have been concerned with cerebellar metabolism or perfusion in Alzheimer's disease. To evaluate cerebellar glucose metabolism in Alzheimer's disease patients, we studied the cerebellar and cerebral metabolic rate for glucose (CMRglc) using 2[18F]fluoro-2-deoxy-D-glucose (18F-FDG) and PET. Methods: Sixty-eight patients with Alzheimer's disease and 13 age-matched normal control subjects were examined. According to scores obtained on the Mini- Mental State Examination (MMSE), Alzheimer's disease patients were classified into three groups: severe (n = 9), moderate (n = 33) and mild (n = 26). Results: The cerebellar glucose metabolism in the severe Alzheimer's disease group was significantly lower (cerebellar glucose metabolism: 5.71 ± 0.62 mg/100 g/min) than that of the control group (6.85 ± 0.66 mg/100 g/min), while temporal and parietal CMRglc were much more decreased. The cerebellar glucose metabolism in the mild and moderate Alzheimer's disease groups also showed lower levels than that of the control group, but the differences did not reach significant levels. Like other cortical CMRglc, the cerebellar glucose metabolism correlated with cognitive impairments. Conclusion: In severe Alzheimer's disease, cerebellar glucose metabolism is significantly reduced. The method of analysis using normalization of regional metabolic data to cerebellar values may be liable to err in severe Alzheimer's disease patients.

Original languageEnglish
Pages (from-to)925-928
Number of pages4
JournalJournal of Nuclear Medicine
Volume38
Issue number6
Publication statusPublished - 1997 Jun 1

Keywords

  • Alzheimer's disease
  • Cerebellum
  • Cerebral glucose metabolism
  • Fluorine-18-fluorodeoxyglucose
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Ishii, K., Sasaki, M., Kitagaki, H., Yamaji, S., Sakamoto, S., Matsuda, K., & Mori, E. (1997). Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease. Journal of Nuclear Medicine, 38(6), 925-928.