Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats

Kazuyuki Hiwatashi, Hitoshi Shirakawa, Kazuyuki Hori, Yumiko Yoshiki, Nao Suzuki, Mika Hokari, Michio Komai, Saori Takahashi

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC50 = 59:9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.

    Original languageEnglish
    Pages (from-to)2310-2312
    Number of pages3
    JournalBioscience, Biotechnology and Biochemistry
    Volume74
    Issue number11
    DOIs
    Publication statusPublished - 2010

    Keywords

    • Blood pressure
    • Renin inhibitor
    • Soyasaponin
    • Soybean
    • Spontaneously hypertensive rat

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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