Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats

Kazuyuki Hiwatashi; Hitoshi Shirakawa; Kazuyuki Hori; Yumiko Yoshiki; Nao Suzuki; Mika Hokari; Michio Komai; Saori Takahashi

doi:10.1271/bbb.100328

Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats

Kazuyuki Hiwatashi, Hitoshi Shirakawa, Kazuyuki Hori, Yumiko Yoshiki, Nao Suzuki, Mika Hokari, Michio Komai, Saori Takahashi

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC₅₀ = 59:9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.

Original language	English
Pages (from-to)	2310-2312
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	11
DOIs	https://doi.org/10.1271/bbb.100328
Publication status	Published - 2010

Keywords

Blood pressure
Renin inhibitor
Soyasaponin
Soybean
Spontaneously hypertensive rat

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.100328

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Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats. / Hiwatashi, Kazuyuki; Shirakawa, Hitoshi; Hori, Kazuyuki; Yoshiki, Yumiko; Suzuki, Nao; Hokari, Mika; Komai, Michio; Takahashi, Saori.

In: Bioscience, Biotechnology and Biochemistry, Vol. 74, No. 11, 2010, p. 2310-2312.

Research output: Contribution to journal › Article › peer-review

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abstract = "The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC50 = 59:9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.",

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note = "Funding Information: We thank Mr. Shimakage (Yamada Foods) for helpful discussions. This study was supported in part by Grant-in-Aid for Scientific Research (no. 20380081) from the Japan Society for the Promotion of Sciences and a grant for the City Area Program from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan.",

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AU - Hiwatashi, Kazuyuki

AU - Shirakawa, Hitoshi

AU - Hori, Kazuyuki

AU - Yoshiki, Yumiko

AU - Suzuki, Nao

AU - Hokari, Mika

AU - Komai, Michio

AU - Takahashi, Saori

N1 - Funding Information: We thank Mr. Shimakage (Yamada Foods) for helpful discussions. This study was supported in part by Grant-in-Aid for Scientific Research (no. 20380081) from the Japan Society for the Promotion of Sciences and a grant for the City Area Program from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan.

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KW - Renin inhibitor

KW - Soyasaponin

KW - Soybean

KW - Spontaneously hypertensive rat

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Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats

Abstract

Keywords

ASJC Scopus subject areas

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