Abstract
The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC50 = 59:9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.
Original language | English |
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Pages (from-to) | 2310-2312 |
Number of pages | 3 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 74 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- Blood pressure
- Renin inhibitor
- Soyasaponin
- Soybean
- Spontaneously hypertensive rat
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry