Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats

Kazuyuki Hiwatashi, Hitoshi Shirakawa, Kazuyuki Hori, Yumiko Yoshiki, Nao Suzuki, Mika Hokari, Michio Komai, Saori Takahashi

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC50 = 59:9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.

Original languageEnglish
Pages (from-to)2310-2312
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number11
DOIs
Publication statusPublished - 2010

Keywords

  • Blood pressure
  • Renin inhibitor
  • Soyasaponin
  • Soybean
  • Spontaneously hypertensive rat

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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