Abstract
To examine the influence of radiation-induced oxidation on the antithrombogenicity of polymers, polytetrafluoroethylene (PTFE) and low density polyethylene (PE) tubes were irradiated with gamma-ray and then treated with water at 50 degree C, and surface characterization and evaluation of their antithrombogenicity were carried out. Irradiation was carried out mainly in argon with 0. 14-0. 47 MR for PTFE and in air or water with 0. 44-8 MR for PE. Data of ESCA and zeta-potential showed the introduction of oxygen-containing groups onto the irradiated surfaces (ca. 10 mol% for the irradiated PE), and the contact angle of water for the PTFE and PE surfaces decreased to 98 degree and 80 degree , respectively. The relative patent time in canine peripheral veins reduced markedly with dose. The reduction in the antithrombogenicity of the irradiated surfaces is mainly due to the enhancement of platelet activation resulting from a decrease in hydrophobicity of the surfaces.
| Original language | English |
|---|---|
| Pages (from-to) | 917-924 |
| Number of pages | 8 |
| Journal | Kobunshi Ronbunshu |
| Volume | 19 |
| Issue number | 4 |
| Publication status | Published - 1987 |
| Externally published | Yes |
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Environmental Science(all)
- Materials Science (miscellaneous)
- Ceramics and Composites
- Polymers and Plastics