REDUCTION IN THE ANTITHROMBOGENICITY OF POLYTETRAFLUOROETHYLENE AND POLYETHYLENE CAUSED BY RADIATION-INDUCED OXIDATION.

Kazuko Hayashi, Hiroshi Fukumura, Susumu Yoshikawa, Noboru Yamamoto, Tetsuo Sakai, Iwao Yamashita

Research output: Contribution to journalArticle

Abstract

To examine the influence of radiation-induced oxidation on the antithrombogenicity of polymers, polytetrafluoroethylene (PTFE) and low density polyethylene (PE) tubes were irradiated with gamma-ray and then treated with water at 50 degree C, and surface characterization and evaluation of their antithrombogenicity were carried out. Irradiation was carried out mainly in argon with 0. 14-0. 47 MR for PTFE and in air or water with 0. 44-8 MR for PE. Data of ESCA and zeta-potential showed the introduction of oxygen-containing groups onto the irradiated surfaces (ca. 10 mol% for the irradiated PE), and the contact angle of water for the PTFE and PE surfaces decreased to 98 degree and 80 degree , respectively. The relative patent time in canine peripheral veins reduced markedly with dose. The reduction in the antithrombogenicity of the irradiated surfaces is mainly due to the enhancement of platelet activation resulting from a decrease in hydrophobicity of the surfaces.

Original languageEnglish
Pages (from-to)917-924
Number of pages8
JournalKobunshi Ronbunshu
Volume19
Issue number4
Publication statusPublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Environmental Science(all)
  • Materials Science (miscellaneous)
  • Ceramics and Composites
  • Polymers and Plastics

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    Hayashi, K., Fukumura, H., Yoshikawa, S., Yamamoto, N., Sakai, T., & Yamashita, I. (1987). REDUCTION IN THE ANTITHROMBOGENICITY OF POLYTETRAFLUOROETHYLENE AND POLYETHYLENE CAUSED BY RADIATION-INDUCED OXIDATION. Kobunshi Ronbunshu, 19(4), 917-924.