Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene

Tomoko Sugawara, Kei Nemoto, Yasuhiro Adachi, Nozomi Yamano, Nobuko Tokuda, Masahiko Muto, Ryuhei Okuyama, Shingo Sakai, Yuji Owada

Research output: Contribution to journalLetterpeer-review

13 Citations (Scopus)

Abstract

Fatty acid binding proteins (FABPs) are capable of binding long-chain FA and are involved in intracellular FA transport and signal transduction. In sebaceous glands, FABP5 is highly expressed in differentiated sebocytes; though, its function remains unclear. In this study, we examined the role of FABP5 in sebocytes using FABP5-deficient mice. The size of sebaceous glands was significantly reduced, while the sebum volume was increased with altered lipid composition in FABP5-deficient mice. However, no significant differences were discerned in the expression of proliferation or differentiation markers including Blimp1, c-myc, Ki67 and peroxisome proliferator-activated receptors (PPAR)γ between wild-type and FABP5-deficient sebaceous glands. The expression of cellular retinoic acid binding protein-2 (CRABP2) that is a competitor of FABP5 for RA signalling was increased in FABP5-deficient mice. These results suggest that FABP5 is involved in the regulation of sebaceous gland activity through modulation of cellular lipid signalling and/or metabolism in the sebocytes.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalExperimental Dermatology
Volume21
Issue number7
DOIs
Publication statusPublished - 2012 Jul

Keywords

  • FABP5
  • Maturation
  • Sebaceous gland
  • Sebocyte

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Fingerprint Dive into the research topics of 'Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene'. Together they form a unique fingerprint.

Cite this