Reduced sensitivity of HeLa cells to cis-platinum by simultaneous overexpression of copper, zinc-superoxide dismutase and catalase

Toshiko Tanaka-Kagawa, Jun Kitahara, Yoshiyuki Seko, Haruka Toyoda, Nobumasa Imura, Akira Naganuma

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The overexpression of catalase or Cu,Zn-superoxide dismutase (Cu,Zn-SOD) did not affect the sensitivity of HeLa cells to cis-platinum. However, the cytotoxicity of cis-platinum was depressed significantly by the simultaneous overexpression of catalase and Cu,Zn-SOD. We concluded that cis-platinum accelerated the generation of superoxide anion in the cells, and the superoxide anion produced was converted into H2O by the cooperative roles of catalase and Cu,Zn-SOD.

Original languageEnglish
Pages (from-to)545-548
Number of pages4
JournalBiochemical Pharmacology
Volume57
Issue number5
DOIs
Publication statusPublished - 1999 Mar 1

Keywords

  • Catalase
  • HeLa cells
  • Reactive oxygen species
  • Resistance
  • Superoxide dismutase
  • cis-platinum

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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