Reduced retention of cadmium in the liver of metallothionein-null mice

Chiharu Tohyama, Masahiko Satoh, Naomi Kodama, Hisao Nishimura, Andy Choo, Anna Michalska, Yoshitaka Kanayama, Akira Naganuma

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The distribution of cadmium (Cd) in the organs of mice was studied using metallothionein (MT)-null transgenic mice. When mice were administered with Cd chloride at a single subcutaneous dose of 1.0 mg Cd/kg body weight, Cd accumulated mainly in the liver and kidney by 6 h after injection without any significant difference between the MT-null mice and control (C57BL/6J) mice. MT was not detected hi these organs of MT-null mice both before and after Cd administration whereas MT was induced mainly in these organs of the control mice. There was a marked elimination of Cd from the liver of MT-null mice by 21 days filter administration, compared with a relatively slow Cd elimination in the C57BL/6J mice. Under the condition that no significant liver or kidney damage was observed, MT was considered to play a significant role in the retention of Cd in the liver but not in the uptake of this metal.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalEnvironmental Toxicology and Pharmacology
Issue number3
Publication statusPublished - 1996 May 15


  • Cadmium
  • Metallothionein
  • Metallothionein-null mice

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Reduced retention of cadmium in the liver of metallothionein-null mice'. Together they form a unique fingerprint.

Cite this