TY - JOUR
T1 - Reduced retention of cadmium in the liver of metallothionein-null mice
AU - Tohyama, Chiharu
AU - Satoh, Masahiko
AU - Kodama, Naomi
AU - Nishimura, Hisao
AU - Choo, Andy
AU - Michalska, Anna
AU - Kanayama, Yoshitaka
AU - Naganuma, Akira
PY - 1996/5/15
Y1 - 1996/5/15
N2 - The distribution of cadmium (Cd) in the organs of mice was studied using metallothionein (MT)-null transgenic mice. When mice were administered with Cd chloride at a single subcutaneous dose of 1.0 mg Cd/kg body weight, Cd accumulated mainly in the liver and kidney by 6 h after injection without any significant difference between the MT-null mice and control (C57BL/6J) mice. MT was not detected hi these organs of MT-null mice both before and after Cd administration whereas MT was induced mainly in these organs of the control mice. There was a marked elimination of Cd from the liver of MT-null mice by 21 days filter administration, compared with a relatively slow Cd elimination in the C57BL/6J mice. Under the condition that no significant liver or kidney damage was observed, MT was considered to play a significant role in the retention of Cd in the liver but not in the uptake of this metal.
AB - The distribution of cadmium (Cd) in the organs of mice was studied using metallothionein (MT)-null transgenic mice. When mice were administered with Cd chloride at a single subcutaneous dose of 1.0 mg Cd/kg body weight, Cd accumulated mainly in the liver and kidney by 6 h after injection without any significant difference between the MT-null mice and control (C57BL/6J) mice. MT was not detected hi these organs of MT-null mice both before and after Cd administration whereas MT was induced mainly in these organs of the control mice. There was a marked elimination of Cd from the liver of MT-null mice by 21 days filter administration, compared with a relatively slow Cd elimination in the C57BL/6J mice. Under the condition that no significant liver or kidney damage was observed, MT was considered to play a significant role in the retention of Cd in the liver but not in the uptake of this metal.
KW - Cadmium
KW - Metallothionein
KW - Metallothionein-null mice
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U2 - 10.1016/1382-6689(96)00014-2
DO - 10.1016/1382-6689(96)00014-2
M3 - Article
C2 - 21781684
AN - SCOPUS:0029937179
VL - 1
SP - 213
EP - 216
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
SN - 1382-6689
IS - 3
ER -