Reduced levels of interleukin-1 receptor antagonist in the cerebrospinal fluid in patients with West syndrome

Kazuhiro Haginoya; Rie Noguchi; Yajuan Zhao; Mitsutoshi Munakata; Hiroyuki Yokoyama; Soichiro Tanaka; Naomi Hino-Fukuyo; Mitsugu Uematsu; Katsuya Yamamoto; Masaru Takayanagi; Kazuie Iinuma; Shigeru Tsuchiya

doi:10.1016/j.eplepsyres.2009.03.013

Reduced levels of interleukin-1 receptor antagonist in the cerebrospinal fluid in patients with West syndrome

Kazuhiro Haginoya, Rie Noguchi, Yajuan Zhao, Mitsutoshi Munakata, Hiroyuki Yokoyama, Soichiro Tanaka, Naomi Hino-Fukuyo, Mitsugu Uematsu, Katsuya Yamamoto, Masaru Takayanagi, Kazuie Iinuma, Shigeru Tsuchiya

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

We measured the levels of pro- and anti-inflammatory cytokines in the cerebrospinal fluid (CSF) of 24 patients with West syndrome to clarify whether inflammatory cytokines were involved in the pathophysiology of West syndrome. There was no significant elevation of any of the three pro-inflammatory cytokines, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, in patients with West syndrome as compared with those in controls. However, level of anti-inflammatory cytokine, IL-1 receptor antagonist was significantly decreased in the CSF of patients with West syndrome. Further study is needed to elucidate whether an immune system disturbance is involved in the pathophysiology of West syndrome.

Original language	English
Pages (from-to)	314-317
Number of pages	4
Journal	Epilepsy Research
Volume	85
Issue number	2-3
DOIs	https://doi.org/10.1016/j.eplepsyres.2009.03.013
Publication status	Published - 2009 Aug

Keywords

Cytokine
ELISA
Infantile spasms
Interleukin
West syndrome

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.eplepsyres.2009.03.013

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title = "Reduced levels of interleukin-1 receptor antagonist in the cerebrospinal fluid in patients with West syndrome",

abstract = "We measured the levels of pro- and anti-inflammatory cytokines in the cerebrospinal fluid (CSF) of 24 patients with West syndrome to clarify whether inflammatory cytokines were involved in the pathophysiology of West syndrome. There was no significant elevation of any of the three pro-inflammatory cytokines, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, in patients with West syndrome as compared with those in controls. However, level of anti-inflammatory cytokine, IL-1 receptor antagonist was significantly decreased in the CSF of patients with West syndrome. Further study is needed to elucidate whether an immune system disturbance is involved in the pathophysiology of West syndrome.",

keywords = "Cytokine, ELISA, Infantile spasms, Interleukin, West syndrome",

author = "Kazuhiro Haginoya and Rie Noguchi and Yajuan Zhao and Mitsutoshi Munakata and Hiroyuki Yokoyama and Soichiro Tanaka and Naomi Hino-Fukuyo and Mitsugu Uematsu and Katsuya Yamamoto and Masaru Takayanagi and Kazuie Iinuma and Shigeru Tsuchiya",

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AU - Haginoya, Kazuhiro

AU - Noguchi, Rie

AU - Zhao, Yajuan

AU - Munakata, Mitsutoshi

AU - Yokoyama, Hiroyuki

AU - Tanaka, Soichiro

AU - Hino-Fukuyo, Naomi

AU - Uematsu, Mitsugu

AU - Yamamoto, Katsuya

AU - Takayanagi, Masaru

AU - Iinuma, Kazuie

AU - Tsuchiya, Shigeru

PY - 2009/8

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AB - We measured the levels of pro- and anti-inflammatory cytokines in the cerebrospinal fluid (CSF) of 24 patients with West syndrome to clarify whether inflammatory cytokines were involved in the pathophysiology of West syndrome. There was no significant elevation of any of the three pro-inflammatory cytokines, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, in patients with West syndrome as compared with those in controls. However, level of anti-inflammatory cytokine, IL-1 receptor antagonist was significantly decreased in the CSF of patients with West syndrome. Further study is needed to elucidate whether an immune system disturbance is involved in the pathophysiology of West syndrome.

KW - Cytokine

KW - ELISA

KW - Infantile spasms

KW - Interleukin

KW - West syndrome

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Reduced levels of interleukin-1 receptor antagonist in the cerebrospinal fluid in patients with West syndrome

Abstract

Keywords

ASJC Scopus subject areas

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