Reduced levels of interleukin-1 receptor antagonist in the cerebrospinal fluid in patients with West syndrome

Kazuhiro Haginoya, Rie Noguchi, Yajuan Zhao, Mitsutoshi Munakata, Hiroyuki Yokoyama, Soichiro Tanaka, Naomi Hino-Fukuyo, Mitsugu Uematsu, Katsuya Yamamoto, Masaru Takayanagi, Kazuie Iinuma, Shigeru Tsuchiya

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

We measured the levels of pro- and anti-inflammatory cytokines in the cerebrospinal fluid (CSF) of 24 patients with West syndrome to clarify whether inflammatory cytokines were involved in the pathophysiology of West syndrome. There was no significant elevation of any of the three pro-inflammatory cytokines, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, in patients with West syndrome as compared with those in controls. However, level of anti-inflammatory cytokine, IL-1 receptor antagonist was significantly decreased in the CSF of patients with West syndrome. Further study is needed to elucidate whether an immune system disturbance is involved in the pathophysiology of West syndrome.

Original languageEnglish
Pages (from-to)314-317
Number of pages4
JournalEpilepsy Research
Volume85
Issue number2-3
DOIs
Publication statusPublished - 2009 Aug 1

Keywords

  • Cytokine
  • ELISA
  • Infantile spasms
  • Interleukin
  • West syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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