Reduced glutathione-resisting 19F NMR sensors for detecting HNO

Narufumi Kitamura, Tatsuhiro Hiraoka, Kazuo Tanaka, Yoshiki Chujo

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The 19F NMR probes for the HNO detection are reported. We synthesized the probe molecules with the paramagnetic Cu(II) complex and fluorine atoms using a cubic silsesquioxane. By using the magnetism changes of the Cu(II) to Cu(I) in the complex by the reduction with HNO, the 19F NMR signal intensities of the probe increased. Noteworthily, our probes have superior resistance to reduced glutathione which is the major intracellular molecule to maintain the reductive environment and the competitor in the reduction of Cu(II) against HNO.

Original languageEnglish
Pages (from-to)4668-4674
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume20
Issue number15
DOIs
Publication statusPublished - 2012 Aug 1
Externally publishedYes

Keywords

  • F NMR probe
  • HNO
  • POSS
  • Paramagnetic relaxation enhancement

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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