Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues

Yasuaki Mohri, Tomohiro Umezu, Shizu Hidema, Hayato Tomisawa, Atsushi Akamatsu, Shigeki Kato, Akihiro Nawa, Katsuhiko Nishimori

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Lgr4 is one of the genes identified as novel G protein-coupled receptor genes designated Lgr4-Lgr8, with high homology with FSH receptor, LH receptor, and TSH receptor genes, but studies of Lgr4-mutant mice have suggested that Lgr4 has essential functions in development. This is the first report describing the relationship between the functions of Lgr4 and female reproductive systems.

Original languageEnglish
Pages (from-to)2878-2881
Number of pages4
JournalFertility and sterility
Volume94
Issue number7
DOIs
Publication statusPublished - 2010 Dec

Keywords

  • Lgr4, K5-Cre-transgenic mice
  • reproductive tract

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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