Reduced Cd4+Cd25+ T cells in patients with idiopathic thrombocytopenic purpura

Miho Sakakura, Hideo Wada, Isao Tawara, Tsutomu Nobori, Takashi Sugiyama, Norimasa Sagawa, Hiroshi Shiku

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Immunoregulatory CD4+CD25+ T cells play an important role in the induction and maintenance of peripheral self-tolerance. These professional regulatory cells prevent the activation and proliferation of potentially autoreactive T cells that have escaped thymic deletion. Therefore, CD4+CD25+ T cells are believed to possibly play an important role in pathogenic autoimmune diseases. We measured the count of CD4+CD25+ T cells in 44 patients with idiopathic thrombocytopenic purpura (ITP), and the number of CD4+CD25+ T cells and clinical features were then analyzed. By using a flow cytometric analysis, the number of CD4+CD25+ T cells in the patients with ITP showed a very wide distribution in comparison to healthy volunteers. The number of CD4+CD25+ T cells was significantly lower in the ITP patients in the severe phase, and in patients positive for anti-glycoprotein IIb-IIIa antibody. However, the number of those cells increased in the patients at the complete remission phase, especially after a splenectomy. The Foxp3 mRNA levels of peripheral blood mononuclear cells (PBMC) of ITP patients were higher with an improved platelet count than in those with a low platelet count. In addition, the Foxp3 mRNA levels closely correlated with the number of CD4+CD25+ cells. These mechanisms remain to be fully elucidated, however, the count of CD4+CD25+ T cells is considered to possibly be related to the severity of ITP.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalThrombosis Research
Volume120
Issue number2
DOIs
Publication statusPublished - 2007 May 21

Keywords

  • CD4CD25 T cells
  • Foxp3
  • ITP
  • Platelet count

ASJC Scopus subject areas

  • Hematology

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    Sakakura, M., Wada, H., Tawara, I., Nobori, T., Sugiyama, T., Sagawa, N., & Shiku, H. (2007). Reduced Cd4+Cd25+ T cells in patients with idiopathic thrombocytopenic purpura. Thrombosis Research, 120(2), 187-193. https://doi.org/10.1016/j.thromres.2006.09.008