Reduced CBF recovery detected by longitudinal 3D-SSP SPECT analyses predicts outcome of postoperative patients after subarachnoid haemorrhage

Tatsushi Mutoh, Tomoko Totsune, Shunsuke Takenaka, Yasuko Tatewaki, Manabu Nakagawa, Jose I. Suarez, Yasuyuki Taki, Tatsuya Ishikawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The aim of this study was to evaluate the impact of cerebral blood flow (CBF) recovery obtained from brain single-photon emission computed tomography (SPECT) images on postoperative outcome after aneurysmal subarachnoid haemorrhage (SAH). Twenty-nine patients who had undergone surgical clipping for ruptured anterior communicating artery aneurysms were analyzed prospectively. Routine measurements of CBF were performed using technetium-99 m hexamethyl propyleneamine oxine SPECT on days 4 and 14 after SAH. Regional voxel data analyzed by three dimensional stereotactic surface projection (3D-SSP) were compared between patients and age-matched normal database (NDB). In 3D-SSP analysis of all patients, cortical hypoperfusion around the surgical site in bilateral frontal lobes was evident on day 4 (P <.05 vs NDB), which was improved significantly on day 14. However, the recovery was less complete in patients with poor clinical grades (P <.05) and presenting symptoms attributable to delayed cerebral ischaemia (DCI) (P <.05) than those without. Multivariate analysis showed that patients with mild to moderate CBF recovery (relative Z-score differences of <4) (P =.014; odds ratio, 2.5; 95% confidence interval, 1.93–3.31) was independently associated with poor functional outcome at 3 months. We conclude that reduced CBF recovery detected by serial 3D-SSP SPECT image analyses can be a potential predictor of poor prognosis in postoperative patients after SAH.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume45
Issue number2
DOIs
Publication statusPublished - 2018 Feb 1

Keywords

  • SPECT
  • cerebral blood flow
  • functional outcome
  • statistical imaging analysis
  • subarachnoid haemorrhage

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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