Redox state of albumin affects its lipid mediator binding characteristics

Makoto Kurano, Keiko Yasukawa, Hitoshi Ikeda, Junken Aoki, Yutaka Yatomi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Depending on its redox status, albumin is known to exist as two forms: reduced albumin or human mercaptalbumin (HMA); and oxidised albumin or human nonmercaptalbumin (HNA). The ratio of HNA to HMA is reportedly elevated in several diseases. Since lipid mediators, such as eicosanoids and lysophospholipids, are typically bound to albumin, we examined the possible preferences of lipid mediators for HNA or HMA. We observed that DHA-derived and EPA-derived eicosanoids preferred to be bound to HMA, while the levels of lysophospholipid mediators, such as lysophosphatidic acids and sphingosine 1-phosphate, were higher in the HNA fraction. Considering the bioactivities reported in previous basic studies, these results suggest that proatherosclerotic lipid mediators might generally prefer HNA, while antiatherosclerotic ones might prefer HMA. Oxidative stress affects the redox status of albumin, which might modulate the dynamism of lipid mediators. This pathway might be partly involved in the association between oxidation and atherosclerosis.

Original languageEnglish
Pages (from-to)892-900
Number of pages9
JournalFree Radical Research
Volume53
Issue number8
DOIs
Publication statusPublished - 2019 Aug 3

Keywords

  • Eicosanoids
  • lysophospholipids
  • mercaptalbumin
  • nonmercaptalbumin
  • phospholipids

ASJC Scopus subject areas

  • Biochemistry

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