Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells

Motohiro Nishida, Akiyuki Nishimura, Tetsuro Matsunaga, Hozumi Motohashi, Shingo Kasamatsu, Takaaki Akaike

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mainly regulated by endogenous electrophiles that are generated from reactive oxygen species, nitric oxide, and the derivative reactive species of nitric oxide during stress responses, as well as by exogenous electrophiles including compounds in foods and environmental pollutants. Among electrophiles formed endogenously, 8-nitroguanosine 3’,5’-cyclic monophosphate (8-nitro-cGMP) has unique cell signaling functions, and pathways for its biosynthesis, signaling mechanism, and metabolism in cells have been clarified. Reactive persulfide species such as cysteine persulfides and polysulfides that are endogenously produced in cells are likely to be involved in 8-nitro-cGMP metabolism. These new aspects of redox biology may stimulate innovative and multidisciplinary research in cardiovascular physiology and pathophysiology. In our review, we focus on the redox-dependent regulation of electrophilic signaling via reduction and metabolism of electrophiles by reactive persulfides in cardiac cells, and we include suggestions for a new therapeutic strategy for cardiovascular disease.

Original languageEnglish
Pages (from-to)132-140
Number of pages9
JournalFree Radical Biology and Medicine
Volume109
DOIs
Publication statusPublished - 2017 Aug 1

Keywords

  • 8-Nitro-cGMP
  • Electrophilic signaling
  • Reactive persulfide species
  • Reductive stress
  • Senescence

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells'. Together they form a unique fingerprint.

  • Cite this