Redox cycling-based electrochemical CMOS imaging sensor for real time and selective imaging of redox analytes

Hiroya Abe, Hiroshi Yabu, Ryota Kunikata, Atsushi Suda, Masahki Matsudaira, Tomokazu Matsue

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

In this study, we have developed a novel electrochemical device (IDEA-Bio-LSI) incorporating interdigitated electrodes array (IDEA) and a LSI-based amperometric device (Bio-LSI) for high speed (4–200 ms) and selective imaging of an analyte diffusion and cellar activities such as dopamine release. The amplification factor (ηamp) and capture efficiency (CE) of IDEA of the device were 2.17 and 0.767, respectively. Compared with previously reported IDE based imaging sensor, the acquisition speed of the present device to acquire one image was improved up to 50–250 times. In addition, the dopamine release from PC12 spheroids in the presence of ascorbic acid was successfully obtained by using the IDEA-Bio-LSI. Therefore, IDEA-Bio-LSI can apply to rapid analyte diffusion biological events such as release of dopamine release.

Original languageEnglish
Article number127245
JournalSensors and Actuators, B: Chemical
Volume304
DOIs
Publication statusPublished - 2020 Feb 1

Keywords

  • Cell analysis
  • Dopamine
  • Electrochemical bioimaging
  • Neurotransmitters
  • Redox cycling

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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