Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: Implications of their possible biological activity and utility

Katsuhiko Ono, Takaaki Akaike, Tomohiro Sawa, Yoshito Kumagai, David A. Wink, Dean J. Tantillo, Adrian J. Hobbs, Peter Nagy, Ming Xian, Joseph Lin, Jon M. Fukuto

Research output: Contribution to journalReview article

207 Citations (Scopus)

Abstract

Hydrogen sulfide (H2S) is an endogenously generated and putative signaling/effector molecule. Despite its numerous reported functions, the chemistry by which it elicits its functions is not understood. Moreover, recent studies allude to the existence of other sulfur species besides H2S that may play critical physiological roles. Herein, the basic chemical biology of H2S as well as other related or derived species is discussed and reviewed. This review particularly focuses on the per- and polysulfides which are likely in equilibrium with free H2S and which may be important biological effectors themselves.

Original languageEnglish
Pages (from-to)82-94
Number of pages13
JournalFree Radical Biology and Medicine
Volume77
DOIs
Publication statusPublished - 2014 Dec

Keywords

  • Hydrogen sulfide
  • Persulfides
  • Polysulfides
  • Thiol redox
  • Thiols

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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