Red light-promoted skin barrier recovery: Spatiotemporal evaluation by transepidermal potential

Yuina Abe, Hajime Konno, Shotaro Yoshida, Takeshi Yamauchi, Kenshi Yamasaki, Mitsuhiro Denda, Matsuhiko Nishizawa

Research output: Contribution to journalArticlepeer-review

Abstract

The light-promoted recovery of epidermal barrier of skin was evaluated by the associated recovery of transepidermal potential (TEP), the potential difference between the surface and dermis of skin, by using porcine skin samples. An accelerated recovery of TEP was observed by irradiation of red light with the irradiance of 40 mW/cm2 and a duration of > 10 min. The influence of the light stimulation to the surroundings (~ 20 mm) was also observed. The irradiations of blue and purple lights were ineffective in accelerating the barrier recovery. These characteristics of the light stimulation would be useful for the design of effective and safe phototherapy devices for skin. The present study proves that the TEP can serve as a spatiotemporal indicator of the epidermal barrier function.

Original languageEnglish
Article numbere0219198
JournalPloS one
Volume14
Issue number7
DOIs
Publication statusPublished - 2019 Jun 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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