TY - JOUR
T1 - Recognition of IgG by Fc receptor and complement
T2 - Effects of glycosidase digestion
AU - Koide, Norio
AU - Nose, Masato
AU - Muramatsu, Takashi
PY - 1977/4/25
Y1 - 1977/4/25
N2 - By extensive glycosidase digestion, most of carbohydrates were removed from IgG antibody against sheep erythrocytes without impairing hemagglutinating activity. The sugar-depleted IgG significantly lost the activities in antibody-dependent cell-mediated cytotoxicity, rosette formation and complement-dependent hemolysis. The results indicated the requirement of the carbohydrate moieties in recognition by Fc receptor and complement. Furthermore differential glycosidase digestion suggested that N-acetylglucosamine or mannose was the key sugar residue required for the maintenance of the activities.
AB - By extensive glycosidase digestion, most of carbohydrates were removed from IgG antibody against sheep erythrocytes without impairing hemagglutinating activity. The sugar-depleted IgG significantly lost the activities in antibody-dependent cell-mediated cytotoxicity, rosette formation and complement-dependent hemolysis. The results indicated the requirement of the carbohydrate moieties in recognition by Fc receptor and complement. Furthermore differential glycosidase digestion suggested that N-acetylglucosamine or mannose was the key sugar residue required for the maintenance of the activities.
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U2 - 10.1016/0006-291X(77)91458-9
DO - 10.1016/0006-291X(77)91458-9
M3 - Article
C2 - 324473
AN - SCOPUS:0017405634
VL - 75
SP - 838
EP - 844
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -