Recognition of IgG by Fc receptor and complement: Effects of glycosidase digestion

Norio Koide, Masato Nose, Takashi Muramatsu

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)


By extensive glycosidase digestion, most of carbohydrates were removed from IgG antibody against sheep erythrocytes without impairing hemagglutinating activity. The sugar-depleted IgG significantly lost the activities in antibody-dependent cell-mediated cytotoxicity, rosette formation and complement-dependent hemolysis. The results indicated the requirement of the carbohydrate moieties in recognition by Fc receptor and complement. Furthermore differential glycosidase digestion suggested that N-acetylglucosamine or mannose was the key sugar residue required for the maintenance of the activities.

Original languageEnglish
Pages (from-to)838-844
Number of pages7
JournalBiochemical and biophysical research communications
Issue number4
Publication statusPublished - 1977 Apr 25

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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