Recent progress in the Morita-Baylis-Hillman reactions

Yoshiharu Iwabuchi, Susumi Hatakeyama

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)

Abstract

The Morita-Baylis-Hillman reaction, α-hydroxyalkylation of activated olefins, has attracted considerable research interest because of the synthetic utility of the densely functionalized product as well as the exquisite tandem Michael-aldol reaction process under nucleophilic catalysis. This review gives an overview on recent remarkable progress in the Morita-Baylis-Hillman reactions. Several other successful methods affording the Morita-Baylis-Hillman type adducts are also reviewed by focusing their imaginative strategies.

Original languageEnglish
Pages (from-to)2-14
Number of pages13
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume60
Issue number1
DOIs
Publication statusPublished - 2002 Jan
Externally publishedYes

Keywords

  • Amine catalyst
  • Asymmetric catalysis
  • Asymmetric synthesis
  • Calcogeno-Baylis-Hillman reactions
  • Diastereoselective reaction
  • Morita-Baylis-Hillman reaction
  • Nucleophilic catalysis
  • Phosphine catalyst
  • Rate enhancement

ASJC Scopus subject areas

  • Organic Chemistry

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