Recent progress in electrochemical HbA1c sensors: A review

Baozhen Wang, Jun Ichi Anzai

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

This article reviews recent progress made in the development of electrochemical glycated hemoglobin (HbA1c) sensors for the diagnosis and management of diabetes mellitus. Electrochemical HbA1c sensors are divided into two categories based on the detection protocol of the sensors. The first type of sensor directly detects HbA1c by binding HbA1c on the surface of an electrode through bio-affinity of antibody and boronic acids, followed by an appropriate mode of signal transduction. In the second type of sensor, HbA1c is indirectly determined by detecting a digestion product of HbA1c, fructosyl valine (FV). Thus, the former sensors rely on the selective binding of HbA1c to the surface of the electrodes followed by electrochemical signaling in amperometric, voltammetric, impedometric, or potentiometric mode. Redox active markers, such as ferrocene derivatives and ferricyanide/ferrocyanide ions, are often used for electrochemical signaling. For the latter sensors, HbA1c must be digested in advance by proteolytic enzymes to produce the FV fragment. FV is electrochemically detected through catalytic oxidation by fructosyl amine oxidase or by selective binding to imprinted polymers. The performance characteristics of HbA1c sensors are discussed in relation to their use in the diagnosis and control of diabetic mellitus.

Original languageEnglish
Pages (from-to)1187-1203
Number of pages17
JournalMaterials
Volume8
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Blood glucose
  • Diabetes mellitus
  • Electrochemical sensor
  • Fructosyl valine sensor
  • Glucose sensor
  • HbA1c sensor

ASJC Scopus subject areas

  • Materials Science(all)

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