The chromophores of the chromoprotein antibiotics C-1027, kedarcidin, and maduropeptin feature a unique nine-membered enediyne structure in the ansa-macrolide ring and show extremely potent cytotoxicity. Their complicated fused ring systems were recently synthesized and the total synthesis of (-)-maduropeptin chromophore was achieved, which thereby led to the revision of its stereochemical structure.
|Number of pages||9|
|Journal||Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry|
|Publication status||Published - 2010 Nov|
ASJC Scopus subject areas
- Organic Chemistry