Recent advances in the synthetic studies of nine-membered enediyne antitumor antibiotics

Itaru Sato, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The chromophores of the chromoprotein antibiotics C-1027, kedarcidin, and maduropeptin feature a unique nine-membered enediyne structure in the ansa-macrolide ring and show extremely potent cytotoxicity. Their complicated fused ring systems were recently synthesized and the total synthesis of (-)-maduropeptin chromophore was achieved, which thereby led to the revision of its stereochemical structure.

Original languageEnglish
Pages (from-to)1123-1131
Number of pages9
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume68
Issue number11
DOIs
Publication statusPublished - 2010 Nov

ASJC Scopus subject areas

  • Organic Chemistry

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