Recent advances in the synthesis of marine polycyclic ether natural products

H. Fuwa, M. Sasaki

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)

Abstract

For more than twenty years, chemists and biologists have been fascinated by the highly complex molecular architectures and the diverse and potent biological activities of marine polycyclic ether natural products. Given the scarce availability of these intriguing substances from natural sources, total chemical synthesis is the only way to obtain sufficient quantities for biological investigation. This review describes recent synthetic advances in the field of marine polycyclic ether natural products and their successful implementation in total synthesis endeavors.

Original languageEnglish
Pages (from-to)784-806
Number of pages23
JournalCurrent Opinion in Drug Discovery and Development
Volume10
Issue number6
Publication statusPublished - 2007 Nov 1

Keywords

  • Convergent synthesis
  • Polycyclic ethers
  • Synthetic strategies
  • Total synthesis
  • Two-directional synthesis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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