Recent advances in the diagnosis and management of autoimmune pancreatitis: Similarities and differences in japan and Korea

Terumi Kamisawa, Ji Kon Ryu, Myung Hwan Kim, Kazuichi Okazaki, Tooru Shimosegawa, Jae Bock Chung

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Two subtypes (types 1 and 2) of autoimmune pancreatitis (AIP) are currently recognized. Type 1 AIP is related to immunoglobulin G4 (lymphoplasmacytic sclerosing pancreatitis), and type 2 AIP is characterized by neutrophilic infiltration into the epithelium of the pancreatic duct (idiopathic duct-centric pancreatitis). Although type 2 AIP is sometimes observed in the United States and Europe, most cases of AIP in Japan and Korea are type 1. The international consensus diagnostic criteria for AIP were created to be applicable worldwide and to distinguish between the two types of AIP. AIP is diagnosed based on the presence of at least one of the five cardinal features (i.e., imaging, serology, other organ involvement, histology, and response to steroid therapy). Oral steroids are the standard therapy for AIP, but immunomodulatory drugs or rituximab have been successfully used for patients with relapsed AIP in the United States and Europe. Generally, the clinical manifestations and demography of AIP are similar between Japan and Korea. However, there are differences in some aspects of the disease, including the proportion of other organ involvement, the prevalence of type 2 AIP, diagnostic criteria and maintenance therapy between the two countries.

Original languageEnglish
Pages (from-to)394-400
Number of pages7
JournalGut and Liver
Volume7
Issue number4
DOIs
Publication statusPublished - 2013 Jul

Keywords

  • Immunoglobulin G
  • Pancreatitis
  • Steroids

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Recent advances in the diagnosis and management of autoimmune pancreatitis: Similarities and differences in japan and Korea'. Together they form a unique fingerprint.

Cite this