Recent advances in molecular pharmacology of the histamine systems: Roles of C-terminal tails of histamine receptors

Atsuo Kuramasu, Jun Sukegawa, Teruyuki Yanagisawa, Kazuhiko Yanai

Research output: Contribution to journalShort surveypeer-review

9 Citations (Scopus)

Abstract

G-protein-coupled receptors (GPCR) represent a large and diverse superfamily of integral membrane proteins to which histamine receptors belong. Increasing numbers of proteins have been identified to interact with the C-termini of GPCRs. These interactions are implicated in targeting, trafficking, and fine-tuning of signaling of GPCRs. Although the C-terminus of the histamine H2 receptor has been suggested to play in agonist-induced internalization of the receptor, roles of the C-termini of the other three histamine receptors are not known. To date, there is no protein identified to interact with the C-termini of histamine receptors.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalJournal of Pharmacological Sciences
Volume101
Issue number1
DOIs
Publication statusPublished - 2006

Keywords

  • C-terminus
  • G-protein-coupled receptor
  • Histamine receptor
  • Internalization

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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