Reassortment between swine influenza A viruses increased their adaptation to humans in pandemic H1N1/09

Yuki Furuse, Akira Suzuki, Hitoshi Oshitani

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

In April 2009, pandemic H1N1/09 influenza, which originated from swine influenza, appeared in North America, and it has since spread globally among humans. It is important to know how swine influenza A virus broke the host barrier to cause a pandemic. We analyzed 673 strains of human, avian, and swine influenza viruses and assessed the internal genes PB2, PB1, PA, NP, M, and NS. Here we found accumulation of mutations in segments that were retained as well as introduced due to genetic reassortment of viruses. The retained segments may have to mutate to accommodate new segments. The mutations caused by interaction among segments retained and introduced due to reassortment between swine influenza viruses may have increased the adaptation of the virus to humans, leading to pandemic H1N1/09. We indicate the sites that probably contributed to the acquisition of efficient human-to-human transmission.

Original languageEnglish
Pages (from-to)569-574
Number of pages6
JournalInfection, Genetics and Evolution
Volume10
Issue number4
DOIs
Publication statusPublished - 2010 May

Keywords

  • Evolution
  • Influenza virus
  • Mutation
  • Pandemic
  • Reassortment

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Reassortment between swine influenza A viruses increased their adaptation to humans in pandemic H1N1/09'. Together they form a unique fingerprint.

Cite this