Reappraisal of Total Pancreatectomy in 45 Patients with Pancreatic Ductal Adenocarcinoma in the Modern Era Using Matched-Pairs Analysis: Multicenter Study Group of Pancreatobiliary Surgery in Japan

Sohei Satoi, Yoshiaki Murakami, Fuyuhiko Motoi, Masayuki Sho, Ippei Matsumoto, Kenichiro Uemura, Manabu Kawai, Masanao Kurata, Hiroaki Yanagimoto, Tomohisa Yamamoto, Masamichi Mizuma, Michiaki Unno, Shoichi Kinoshita, Takahiro Akahori, Makoto Shinzeki, Takumi Fukumoto, Yasushi Hashimoto, Seiko Hirono, Hiroki Yamaue, Goro HondaMasanori Kwon

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Objective The aim of this study was to reappraise the clinical role of total pancreatectomy with curative intent in patients with pancreatic ductal adenocarcinoma (PDAC). Methods In 2001 to 2011 database from 7 institutions in Japan, 45 (3.1%) of 1451 patients with PDAC underwent total pancreatectomy (TP group), and 885 patients underwent pancreaticoduodenectomy (PD group). A matched-pairs group consisted of 45 patients matched for age, sex, year, resectability status, and neoadjuvant therapy (matched-PD group). Clinicopathological data, overall survival, and disease-free survival were compared between groups. Results Clinical features of the TP group revealed higher-stage disease, greater surgical stress, a higher frequency of lymph node metastasis, and a lower adjuvant chemotherapy completion rate compared with the PD group (P < 0.05). Overall survival and disease-free survival in the TP group were significantly worse than those in the PD group (P < 0.05). Multivariate analysis revealed resectability status, neoadjuvant therapy, blood transfusion, lymph node metastasis, and adjuvant therapy to be significant prognostic factors. No differences in mortality and morbidity rates were observed between the 2 groups. A matched-pairs analysis revealed similar surgical outcomes and overall survival. Conclusions The surgical outcome of total pancreatectomy for patients with PDAC is acceptable. When margin-negative resection is expected, total pancreatectomy should not be abandoned in the modern era.

Original languageEnglish
Pages (from-to)1003-1009
Number of pages7
JournalPancreas
Volume45
Issue number7
DOIs
Publication statusPublished - 2016 Aug 1

Keywords

  • matched-pairs analysis
  • mortality and morbidity
  • overall survival
  • pancreatic ductal adenocarcinoma

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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