Real-time monitoring transcranial sub-megahertz ultrasound thrombolysis with phased array scanner

Jun Kubota, Makoto Ogihara, Takashi Azuma, Shin Ichiro Umemura, Akira Sasaki, Kazumi Ando, Jun Shimizu, Toshihiro Ishibashi, Yasumasa Tanifuji, Hiroshi Furuhata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Transcranial ultrasonic thrombolytic system has been developed, for acute ischemic stroke (AIS) therapy during hyper acute phase. The system aims to have a higher potential for early recanalization in the thrombo-embolism by accelerating the effect of thrombolytic agent with transcranial ultrasonication. Sub MHz ultrasound has less attenuation by several orders through cranium than that of more than 2MHz, while it has higher risk of intracranial hemorrhage. In order to avoid the risk, the direction of therapeutic ultrasound (T) beam is targeted at an area around the embolic artery, and in order to minimize mechanical and thermal adverse biological effects, T-beam frequency is selected 500 kHz, the acoustic intensity limited less than the maximum regulation level of the diagnostic ultrasound equipment. The transcranial diagnostic (Doppler or color flow imaging) ultrasound (D) beam at 2MHz is used for monitoring the recanalization. The system irradiates both T- and D-beam alternately in the signal control subsystem through a phased array single compound probe. The images by the diagnostic array in the probe are comparable to those by the commercialized sector scanning diagnostic phased array. The probe also has supplied T-beam of the maximum acoustic intensity designated by the regulation for the diagnostic equipment. The margin of safety was confirmed through animal experiments.

Original languageEnglish
Title of host publication2005 IEEE Ultrasonics Symposium
Pages1716-1719
Number of pages4
DOIs
Publication statusPublished - 2005 Dec 1
Event2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands
Duration: 2005 Sep 182005 Sep 21

Publication series

NameProceedings - IEEE Ultrasonics Symposium
Volume3
ISSN (Print)1051-0117

Other

Other2005 IEEE Ultrasonics Symposium
CountryNetherlands
CityRotterdam
Period05/9/1805/9/21

Keywords

  • Color flow imaging
  • Doppler
  • Thrombolysis
  • Transcranial ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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