Real-time analysis of isoprene in breath by using ultraviolet-absorption spectroscopy with a hollow optical fiber gas cell

Takuro Iwata, Takashi Katagiri, Yuji Matsuura

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A breath analysis system based on ultraviolet-absorption spectroscopy was developed by using a hollow optical fiber as a gas cell for real-time monitoring of isoprene in breath. The hollow optical fiber functions as an ultra-small-volume gas cell with a long path. The measurement sensitivity of the system was evaluated by using nitric-oxide gas as a gas sample. The evaluation result showed that the developed system, using a laser-driven, high-intensity light source and a 3-m-long, aluminum-coated hollow optical fiber, could successfully measure nitric-oxide gas with a 50 ppb concentration. An absorption spectrum of a breath sample in the wavelength region of around 200-300 nm was measured, and the measured spectrum revealed the main absorbing components in breath as water vapor, isoprene, and ozone converted from oxygen by radiation of ultraviolet light. The concentration of isoprene in breath was estimated by multiple linear regression. The regression analysis results showed that the proposed analysis system enables real-time monitoring of isoprene during the exhaling of breath. Accordingly, it is suitable for measuring the circadian variation of isoprene.

Original languageEnglish
Article number2058
JournalSensors (Switzerland)
Volume16
Issue number12
DOIs
Publication statusPublished - 2016 Dec 5

Keywords

  • Breath analysis
  • Hollow-optical fiber
  • Isoprene
  • Ultraviolet spectroscopy

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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