Reactivity of electrochemically concentrated anhydrous [ 18F]fluoride for microfluidic radiosynthesis of 18F-labeled compounds

Rebecca Wong, Ren Iwata, Hidekazu Saiki, Shozo Furumoto, Yoichi Ishikawa, Eiichi Ozeki

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29 Citations (Scopus)


In order to demonstrate the usefulness of electrochemically concentrated [ 18F]fluoride the reactivity of the [K +/K.222] 18F - complex concentrated in an aprotic solvent (ca. 60μL) was evaluated via nucleophilic 18F-substitution reactions through radiosynthesis of [ 18F]FDG, [ 18F]FMISO, [ 18F]flumazenil and [ 18F]fluoromethyl bromide. The substitutions were carried out in a microfluidic reaction flow cell and the effects of reaction time, temperature, precursor concentration and reaction solvent on the 18F-substitution yields were investigated. The 18F-fluorination yields for the four 18F-labeled compounds under optimized conditions (98% for protected [ 18F]FDG, 80% for protected [ 18F]FMISO, 20% for [ 18F]flumazenil and 60% for [ 18F]fluoromethyl bromide) were comparable to or higher than those obtained by conventional means. In this study it is clearly demonstrated that electrochemically concentrated [ 18F]fluoride enables microfluidic radiosynthesis by effectively reducing synthesis times and especially by increasing radiochemical yields of products labile at high temperatures.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalApplied Radiation and Isotopes
Issue number1
Publication statusPublished - 2012 Jan


  • F-18
  • Microfluidics
  • PET probe
  • Radiosynthesis
  • [ F]fluoride

ASJC Scopus subject areas

  • Radiation


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