TY - JOUR
T1 - Reactivation of hepatitis C virus with severe hepatitis flare during steroid administration for interstitial pneumonia
AU - Sato, Kosuke
AU - Inoue, Jun
AU - Kakazu, Eiji
AU - Ninomiya, Masashi
AU - Iwata, Tomoaki
AU - Sano, Akitoshi
AU - Tsuruoka, Mio
AU - Masamune, Atsushi
N1 - Funding Information:
JI received research grants from Gilead Sciences and AbbVie GK. The other authors state that they have no conflict of interest.
Publisher Copyright:
© 2021, Japanese Society of Gastroenterology.
PY - 2021/8
Y1 - 2021/8
N2 - Hepatitis C virus reactivation (HCVr) was defined previously as an increase in HCV RNA level of ≥ 1 log10 IU/mL from baseline HCV RNA level after chemotherapies or immunosuppressive therapies, but HCVr during a steroid monotherapy has rarely been reported. Here we report a 75-year-old Japanese female with chronic hepatitis C (genotype 2a) who developed HCVr after the administration of prednisolone for interstitial pneumonia. She experienced alanine aminotransferase (ALT) flare with icterus, but after the tapering of prednisolone and a liver supporting therapy, levels of HCV RNA and ALT were gradually decreased. Then, she received an anti-viral therapy with sofosbuvir/ledipasvir. Although HCV relapsed 4 weeks after the therapy, a second therapy with glecaprevir/pibrentasvir was successful. This case suggests that HCVr with hepatitis flare can occur even after a steroid monotherapy, and we should pay attention to HCVr when we administer prednisolone for patients with HCV chronic infection.
AB - Hepatitis C virus reactivation (HCVr) was defined previously as an increase in HCV RNA level of ≥ 1 log10 IU/mL from baseline HCV RNA level after chemotherapies or immunosuppressive therapies, but HCVr during a steroid monotherapy has rarely been reported. Here we report a 75-year-old Japanese female with chronic hepatitis C (genotype 2a) who developed HCVr after the administration of prednisolone for interstitial pneumonia. She experienced alanine aminotransferase (ALT) flare with icterus, but after the tapering of prednisolone and a liver supporting therapy, levels of HCV RNA and ALT were gradually decreased. Then, she received an anti-viral therapy with sofosbuvir/ledipasvir. Although HCV relapsed 4 weeks after the therapy, a second therapy with glecaprevir/pibrentasvir was successful. This case suggests that HCVr with hepatitis flare can occur even after a steroid monotherapy, and we should pay attention to HCVr when we administer prednisolone for patients with HCV chronic infection.
KW - Direct acting antivirals
KW - HCV reactivation
KW - Prednisolone
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U2 - 10.1007/s12328-021-01432-4
DO - 10.1007/s12328-021-01432-4
M3 - Article
C2 - 33983567
AN - SCOPUS:85105633709
VL - 14
SP - 1221
EP - 1226
JO - Clinical Journal of Gastroenterology
JF - Clinical Journal of Gastroenterology
SN - 1865-7257
IS - 4
ER -
