Reaction stereochemistry of 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine

Eriko Nango, Fumitaka Kudo, Tadashi Eguchi, Katsumi Kakinuma

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The reaction stereochemistry of 2-deoxy-scyllo-inosose (DOI) synthase (DOIS) derived from butirosin-producing Bacillus circulans, the key starter enzyme of 2-deoxystreptamine biosynthesis, was closely analyzed by use of the purified recombinant DOIS. The stereochemical pathway of the DOIS reaction is common in the aminoglycoside-producing Bacillus and Streptomyces, but is distinct from a related dehydroquinate synthase reaction in the shikimate pathway. Evolutionary relationship between these enzymes is also discussed.

Original languageEnglish
Pages (from-to)438-439
Number of pages2
JournalChemistry Letters
Volume32
Issue number5
DOIs
Publication statusPublished - 2003 May 5
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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