The reactions of 2,6-di-tert-butyl-4-methoxyphenyl 2-methoxybenzoate 1a with several organolithium and -magnesium reagents are found to give the methoxy-substitution products 2 and/or the conjugate addition products to the benzoate ring (3 and 4), preferring the latter products at the expense of the former with the increase of the electron-donating ability of the carbanion species. A SET mechanism is proposed for the conjugate addition.
|Number of pages||4|
|Publication status||Published - 1995 Jan 1|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry