Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor

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Abstract

We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling. This journal is

Original languageEnglish
Pages (from-to)499-502
Number of pages4
JournalRSC Chemical Biology
Volume2
Issue number2
DOIs
Publication statusPublished - 2021 Apr

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Chemistry (miscellaneous)

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